42998-44-7Relevant academic research and scientific papers
Approaches to the Synthesis of Cytochalasans. Part 3. Synthesis of a Substituted Tetrahydroisoindolinone Moiety Possessing the Same Relative Configuration as Proxiphomin
Schmidlin, Tibur,Zuercher, Werner,Tamm, Christoph
, p. 235 - 250 (1981)
The total synthesis of the tetrahydroisoindolinone moiety corresponding to proxiphomin (1) is described, bearing functional groups for the attachment of the macrocyclic ring.Knoevenagel-Cope condensation of racemic 2-(benzyloxycarbonylamino)-3-phenylpropa
Synthesis of phenylalanine analogs
Chang, Meng-Yang,Lin, Chun-Yu,Sun, Pei-Pei
, p. 1061 - 1067 (2007/10/03)
A straight forward synthesis of phenylalanine analogs is described. Cerium ammonium nitrate (CAN) mediated addition of azide to cinnamicester, followed by reaction with sodium acetate aff orded the α-azidocinnamate in moderate yield. Hydrogenation of α-azidocinnamate, followed by BOC, CBZ or Fmoc protection gave phenylalanine analogs. A new approach for synthesizing racemic p-boronophenylalanine analog was also explored.
Poststatin, a new inhibitor of prolyl endopeptidase. V. Endopeptidase inhibitory activity of poststatin analogues
Tsuda, Makoto,Muraoka, Yasuhiko,Nagai, Machiko,Aoyagi, Takaaki,Takeuchi, Tomio
, p. 890 - 899 (2007/10/03)
Thirty analogues of poststatin were synthesized, and their inhibitory activities against prolyl endopeptidase, human leukocyte elastase and cathepsin B were measured. The α-ketone was essential and the S configuration was preferable to the R configuration in the β-substituted-β-amino-α-oxopropionic acid moiety of poststatin analogues for endopeptidase inhibitory activity. The analogue in which the D-leucine residue of poststatin was replaced by L-leucine showed strong inhibitory activity to cathepsin B. Introduction of an aromatic group into the P4 position and proline into the P2 position increased inhibitory activity to elastase. Benzyloxycarbonyl-L-homophenylalanyl-(RS)-3-amino-2-oxovaleryl-D- leucyl-L-valine was about 6 times more active to prolyl endopeptidase than natural poststatin.
A concise and stereoselective synthesis of threo-γ-hydroxy-L-β-lysine lactone
Misiti, Domenico,Zappia, Giovanni,Delle Monache, Giuliano Delle
, p. 235 - 238 (2007/10/03)
A stereoselective synthesis of threo-γ-hydroxy-β-L-lysine lactone is reported. The threo-amino alcohol functionality is introduced by iodine-mediated cyclocarbamation of the electron poor allylamine 6. The D-phenylalanine was used as starting material as
