1060759-62-7Relevant articles and documents
Design, synthesis and anticancer activity evaluation of novel C14 heterocycle substituted epi-triptolide
Xu, Hongtao,Tang, Huanyu,Feng, Huijin,Li, Yuanchao
, p. 46 - 55 (2014/01/17)
Two series of novel C14 heterocycle substituted epi-triptolide derivatives as potential anticancer agents were synthesized and tested for their cytotoxicity against SKOV-3 and PC-3 tumor cell lines. The introduction of C14β-aryl heterocycle aminomethyl su
Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents
Li, Zheng,Zhou, Zhao-Li,Miao, Ze-Hong,Lin, Li-Ping,Feng, Hui-Jin,Tong, Lin-Jiang,Ding, Jian,Li, Yuan-Chao
experimental part, p. 5115 - 5123 (2010/03/25)
It has long been considered that the free β hydroxyl group at C14 of triptolide (1) is essential to its potent anticancer activity. In this study, we synthesized novel derivatives of 1 with a hydroxyl group substituted by epoxy groups (4-8) or a five-memb
