1060805-66-4

Basic information

• Product Name: 4-bromo-6-chloropicolinic acid
• Synonyms: 4-bromo-6-chloropicolinic acid;4-Bromo-6-chloro-2-pyridinecarboxylic acid;4-Bromo-6-chloro-pyridine-2-carboxylic acid
• CAS NO: 1060805-66-4
• Molecular Formula: C6H3BrClNO2
• Molecular Weight: 236
• Mol File: 1060805-66-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 371.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.917
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.88±0.10(Predicted)
• CAS DataBase Reference: 4-bromo-6-chloropicolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-6-chloropicolinic acid(1060805-66-4)
• EPA Substance Registry System: 4-bromo-6-chloropicolinic acid(1060805-66-4)

Safety Data

• Hazardous Substances Data: 1060805-66-4(Hazardous Substances Data)

Usage

Uses

4-Bromo-6-chloro-2-pyridinecarboxylic Acid, can be used in the synthesis of Naphthyridone p38 MAP kinase inhibitor, which is potentially useful for the treatment of rheumatoid arthritis and psoriasis.

Upstream product

• 1206250-53-4 4-bromo-2-chloro-6-methylpyridine 
• 3749-51-7 2,4-dihydroxy-6-methylpyridine 

Relevant articles and documents

Preparation method of 4-bromo-6-chloropyridine-2-carboxylic acid

The invention relates to a preparation method of 4-bromo-6-chloropyridine-2-carboxylic acid. The preparation method of the 4-bromo-6-chloropyridine-2-carboxylic acid comprises the following steps: carrying out primary substitution reaction on 2,4-dihydroxy-6-methylpyridine and one of phosphorus oxybromide, phosphorus pentabromide or tetrabutylammonium bromide to generate 2-hydroxy-4-bromo-6-methylpyridine; carrying out secondary substitution reaction on the 2-hydroxy-4-bromine-6-methyl pyridine and phosphorus oxychloride or phosphorus pentachloride to generate 4-bromine-6-methyl-2-pyridine; according to the preparation method of the 4bromo 6chloropyridine 2carboxylic acid, the raw materials are cheap and easy to obtain, column chromatography purification is not needed in the reaction process, and the operation is simple and convenient.