1060815-87-3Relevant academic research and scientific papers
Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases
Akaki, Tatsuo,Bessho, Yuki,Ito, Takashi,Fujioka, Shingo,Ubukata, Minoru,Mori, Genki,Yamanaka, Kenji,Orita, Takuya,Doi, Satoki,Iwanaga, Tomoko,Ikegashira, Kazutaka,Hantani, Yoshiji,Nakanishi, Isao,Adachi, Tsuyoshi
, (2021)
A fragment-based lead discovery approach was applied to Pyruvate Dehydrogenase Kinases (PDHKs) to discover inhibitors against the ATP binding site with novel chemotypes. X-ray fragment screening toward PDHK4 provided a fragment hit 1 with a characteristic
