71149-52-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine is utilized as a building block for the synthesis of biologically active compounds, contributing to the development of new pharmaceuticals. Its unique structure allows for the creation of diverse molecules with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine serves as a precursor for the synthesis of active ingredients in pesticides and other agrochemical products, enhancing crop protection and yield.
Used in Research and Development:
4-Chloro-2-methyl-1H-pyrrolo[2,3-d]pyrimidine is employed as a reagent or intermediate in research settings, facilitating the preparation of other organic compounds and aiding in the discovery of new chemical entities with potential applications in various fields.

InChI:InChI=1/C7H6ClN3/c1-4-10-6(8)5-2-3-9-7(5)11-4/h2-3H,1H3,(H,9,10,11)

Upstream product

• 1111237-76-3 5-bromo-4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 74-88-4 methyl iodide 
• 1314922-47-8 2-methyl-4-hydroxypyrrolo[2,3-d]pyrimidine 
• 89792-11-0 2-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one 
• 52133-67-2 ethyl 2-cyano-4,4-diethoxybutyrate 

Downstream Products

• 85250-96-0 (3-Methoxy-phenyl)-(2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 
• 85250-77-7 (2-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-p-tolyl-amine 
• 85250-73-3 (4-Chloro-phenyl)-(2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 
• 85250-84-6 1-[4-(2-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-phenyl]-ethanone 
• 85251-08-7 (2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-phenethyl-amine 
• 85250-93-7 (3-Chloro-phenyl)-(2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 
• 85250-83-5 (4-Ethoxy-phenyl)-(2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 
• 85267-30-7 (4-Butyl-phenyl)-(2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 
• 85250-86-8 (2-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(4-trifluoromethyl-phenyl)-amine 
• 85250-88-0 (4-Isopropyl-phenyl)-(2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 
• 85250-87-9 (2-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(4-propyl-phenyl)-amine 
• 85250-95-9 (2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-m-tolyl-amine 
• 85250-94-8 (3-Iodo-phenyl)-(2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 
• 85250-91-5 (2-Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-o-tolyl-amine 

Relevant academic research and scientific papers

Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases

A fragment-based lead discovery approach was applied to Pyruvate Dehydrogenase Kinases (PDHKs) to discover inhibitors against the ATP binding site with novel chemotypes. X-ray fragment screening toward PDHK4 provided a fragment hit 1 with a characteristic

Preparation method for catalyzing pyrimidine cyclic hydroxyl chlorination by tetraethylammonium chloride

The invention discloses a preparation method for catalyzing pyrimidine cyclic hydroxyl chlorination by tetraethylammonium chloride, which comprises the following steps: (1) adding phosphorus oxychloride into a container, adding tetraethylammonium chloride as a catalyst, adding a pyrimidine cyclic hydroxyl compound, and heating to react; (2) preparing an alkali liquor, cooling to 0 DEG C, and slowly dropwise adding an obtained reaction liquid into the alkali liquor for quenching to obtain a target product. The method has the advantages that the provided pyrimidine cyclic hydroxyl chlorination catalysis method is small in environmental pollution, the obtained product is light in color, the catalysis efficiency is high, and the phosphorus oxychloride recovery pressure is small.

SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS

Compounds of the general formula:processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE

The present invention discloses substituted pyrimidine and pyrimido indole compounds and optionally pharmaceutically acceptable salts, hydrates or solvates thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt, hydrate, or solvate thereof.

PIPERIDINE SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)

The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further conce

Synthesis, cytostatic, antimicrobial, and anti-HCV activity of 6-substituted 7-(het)aryl-7-deazapurine ribonucleosides

A series of 80 7-(het)aryl- and 7-ethynyl-7-deazapurine ribonucleosides bearing a methoxy, methylsulfanyl, methylamino, dimethylamino, methyl, or oxo group at position 6, or 2,6-disubstituted derivatives bearing a methyl or amino group at position 2, were

Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance

Two classes of molecules were designed and synthesized based on a 6-CH 3 cyclopenta[d]pyrimidine scaffold and a pyrrolo[2,3-d]pyrimidine scaffold. The pyrrolo[2,3-d]pyrimidines were synthesized by reacting ethyl 2-cyano-4,4-diethoxybutanoate an

BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF

The present invention provides bicyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor a

FUSED HETEROARYL PYRIDYL AND PHENYL BENZENESUFLONAMIDES AS CCR2 MODULATORS FOR THE TREAMENT OF INFLAMMATION

Compounds are provided that act as potent antagonists of the CCR2 receptor. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2- mediated diseases and as controls in assays for the identification of CCR2 antagonists. A compound of the formula (I) or a salt thereof: where: R1 and R2 are each independently hydrogen, halogen, C1-8alkyl, -CN. or C1-8 haloalkyl, provided that at least one of R11or R2 is other than hydrogen; each R3 is independently hydrogen; R4 is hydrogen; R5 is halogen or C1-8 alkyl; R6 is hydrogen; X1 is CR7, N or NO; X2 and X4 are N or NO; X3 is CR7; X6 and X7 are each independently selected from CR7, N, and NO; each R7 is independently selected from the group consisting of hydrogen, halogen, substituted or unsubstituted C2-8 alkyl, substituted or unsubstituted C2-8 alkeπyl, substituted or unsubstituted C2-8 alkynyl, -CN. =O, -NO2, -OR6, -OC(O)R8, -CO2R8, -C(O)R8, -C(O)NR0R8, -OC(O)NR9R8, -NR10C(O)R8, -NR10C(O)NR9R8, -NR9R8, -NR10CO2R8, -SR8, -S(O)R8, -S(O)2R8, -S(O)2NR9R8, -NR10S(O)2R8, substituted or unsubstituted C6-10 aryl, substituted or unsubstituted 5- to 10-membered heteroaryl and substituted or unsubstituted 3- to 10-membered heterocyclyl;