106112-20-3

Basic information

• Product Name: Benzeneacetonitrile, alpha-methyl-4-(1-methylethyl)- (9CI)
• Synonyms: Benzeneacetonitrile, alpha-methyl-4-(1-methylethyl)- (9CI)
• CAS NO: 106112-20-3
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.2542
• Product Categories: ISOPROPYL
• Mol File: 106112-20-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetonitrile, alpha-methyl-4-(1-methylethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, alpha-methyl-4-(1-methylethyl)- (9CI)(106112-20-3)
• EPA Substance Registry System: Benzeneacetonitrile, alpha-methyl-4-(1-methylethyl)- (9CI)(106112-20-3)

Safety Data

• Hazardous Substances Data: 106112-20-3(Hazardous Substances Data)

Upstream product

• 13372-43-5 p-Isopropyl-α-methylbenzylchlorid 
• 59770-99-9 (+/-)-1-bromo-1-(4-isopropylphenyl)ethane 
• 104-47-2 p-methoxybenzylnitrile 
• 23741-79-9 Isopropylmalonsauredinitril 
• 2055-40-5 4-isopropylstyrene 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 4395-87-3 (4-isopropylphenyl)acetonitrile 
• 74-88-4 methyl iodide 
• 14191-95-8 4-cyanomethylphenol 
• 100-39-0 benzyl bromide 

Relevant articles and documents

Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control

Reversible catalytic reactions operate under thermodynamic control, and thus, establishing a selective catalytic system poses a considerable challenge. Herein, we report a reversible transfer hydrocyanation protocol that exhibits high selectivity for the thermodynamically less favorable branched isomer. Selectivity is achieved by exploiting the lower barrier for C-CN oxidative addition and reductive elimination at benzylic positions in the absence of a cocatalytic Lewis acid. Through the design of a novel type of HCN donor, a practical, branched-selective, HCN-free transfer hydrocyanation was realized. The synthetically useful resolution of a mixture of branched and linear nitrile isomers was also demonstrated to underline the value of reversible and selective transfer reactions. In a broader context, this work demonstrates that high kinetic selectivity can be achieved in reversible transfer reactions, thus opening new horizons for their synthetic applications.

Sulphonamide derivatives

Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formulaR1—L—NHSO2R2??Iin whichR1 represents an unsubstituted or substituted aromatic or heteroaromatic group;R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; andL represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring;and pharmaceutically acceptable salts thereof.Also disclosed are compounds of formula I, processes for preparing them and pharmaceutical compositions containing them.

An Easy Access to α-Aryl Alkyl Nitriles

The preparation of α-aryl alkyl nitriles (2), precursors of the nonstereoidal antiinflammatory α-arylaliphatic acids, via the displacement of the corresponding halides with sodium cyanide employing benzyltriethylammonium chloride as catalyst in acetonitrile in 70-85percent yield (>95percent purity), is described.