1061307-56-9

Usage

Uses

Used in Coordination Chemistry:
R-2-[bis[3,5-bis(trifluoroMethyl)phenyl][(triethylsilyl)oxy]Methyl]-Pyrrolidine is used as a ligand for metal ions in coordination chemistry, providing stability and enhancing the reactivity of the metal ions in various chemical reactions.
Used in Catalysis:
R-2-[bis[3,5-bis(trifluoroMethyl)phenyl]
[(triethylsilyl)oxy]Methyl]-Pyrrolidine serves as a catalyst in various chemical processes, leveraging its reactive nature and ability to chelate metal ions, which can improve the efficiency and selectivity of the reactions.
Used in Organic Synthesis:
R-2-[bis[3,5-bis(trifluoroMethyl)phenyl][(triethylsilyl)oxy]Methyl]-Pyrrolidine is utilized in organic synthesis due to its versatility and reactivity, enabling the formation of complex organic molecules and facilitating specific chemical transformations.
Used in Pharmaceutical Research:
In the pharmaceutical industry, the compound is employed in research for its potential applications in drug development, taking advantage of its unique properties and reactivity to design and synthesize novel pharmaceutical agents.
Used in Chemical Applications:
R-2-[bis[3,5-bis(trifluoroMethyl)phenyl][(triethylsilyl)oxy]Methyl]-Pyrrolidine is used in various chemical applications, capitalizing on its hydrophobicity and electron-withdrawing effects to enhance the performance of chemical processes and products.

Upstream product

• 948595-00-4 (R)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol 
• 79271-56-0 triethylsilyl trifluoromethyl sulfonate 
• 344-25-2 D-Prolin 
• 328-70-1 3,6-bis(trifluoromethyl)bromobenzene 
• 185246-66-6 1-ethyl methyl (2R)-pyrrolidine-1,2-dicarboxylate 
• 1146629-85-7 (7aR)-1,1-bis(3,5-bis(trifluoromethyl)phenyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one 

Relevant academic research and scientific papers

Enantioselective Total Synthesis of (+)-Heilonine

Chemical transformations that rapidly and efficiently construct a high level of molecular complexity in a single step are perhaps the most valuable in total synthesis. Among such transformations is the transition metal catalyzed [2 + 2 + 2] cycloisomerization reaction, which forges three new C-C bonds and one or more rings in a single synthetic operation. We report here a strategy that leverages this transformation to open de novo access to the Veratrum family of alkaloids. The highly convergent approach described herein includes (i) the enantioselective synthesis of a diyne fragment containing the steroidal A/B rings, (ii) the asymmetric synthesis of a propargyl-substituted piperidinone (F ring) unit, (iii) the high-yielding union of the above fragments, and (iv) the intramolecular [2 + 2 + 2] cycloisomerization reaction of the resulting carbon framework to construct in a single step the remaining three rings (C/D/E) of the hexacyclic cevanine skeleton. Efficient late-stage maneuvers culminated in the first total synthesis of heilonine (1), achieved in 21 steps starting from ethyl vinyl ketone.

PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS

The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

Enantioselective synthesis of janus kinase inhibitor INCB018424 via an organocatalytic aza-michael reaction

An enantioselective synthesis of INCB018424 via organocatalytic asymmetric aza-Michael addition of pyrazoles (16 or 20) to (E)-3- cyclopentylacrylaldehyde (23) using diarylprolinol silyl ether as the catalyst was developed. Michael adducts (R)-24 and (R)-27 were isolated in good yield and high ee and were readily converted to INCB018424.