1061578-75-3Relevant academic research and scientific papers
Functionalized 2-amino-α-L-LNA: Directed positioning of intercalators for DNA targeting
Kumar, T.Santhosh,Madsen, Andreas S.,stergaard, Michael E.,Sau, Sujay P.,Wengel, Jesper,Hrdlicka, Patrick J.
experimental part, p. 1070 - 1081 (2009/08/15)
Chemically modified oligonucleotides are increasingly applied in nucleic acid based therapeutics and diagnostics. LNA (locked nucleic acid) and its diastereomer α-L-LNA are two promising examples thereof that exhibit increased thermal and enzymatic stabil
Synthesis and biophysical studies of N2′-functionalized 2′-amino-α-L-LNA
Kumar, T. Santhosh,Madsen, Andreas S.,Wengel, Jesper,Hrdlicka, Patrick J.
, p. 1403 - 1405 (2008/09/18)
A synthetic route towards a selected set of N-acylated and N-alkylated derivatives of 2′-amino-α-L-LNA phosphoramidite building blocks has been developed. Biophysical studies suggest that the 2-oxo-5-azabicyclo[2.2.1] heptane skeleton of 2′-amino-α-L-LNA
