866611-96-3

Upstream product

• 894430-46-7 (1S,3R,4S,7R)-7-benzyloxy-1-(4,4'-dimethoxytrityloxymethyl)-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-62-7 1-[(1S,3R,4S,7R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-7-hydroxy-5-(2,2,2-trifluoro-acetyl)-2-oxa-5-aza-bicyclo[2.2.1]hept-3-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 894430-61-6 Acetic acid (1S,3R,4S,7R)-7-benzyloxy-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-(2,2,2-trifluoro-acetyl)-2-oxa-5-aza-bicyclo[2.2.1]hept-1-ylmethyl ester 
• 894430-60-5 Methanesulfonic acid (1S,3R,4S,7R)-7-benzyloxy-3-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-(2,2,2-trifluoro-acetyl)-2-oxa-5-aza-bicyclo[2.2.1]hept-1-ylmethyl ester 
• 894430-51-4 (1R,6R,7S,8S,10S,11R,12S)-10-acetoxymethyl-11-benzyloxy-6-methyl-13-oxa-2,4,8-triazatetracyclo[8.2.1.0^2,7.0^8,12]tridecan-3,5-dione 
• 894430-47-8 (1S,3R,4S,7R)-7-hydroxy-1-hydroxymethyl-3-(thymin-1-yl)-5-trifluoroacetyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 410076-92-5 3-O-benzyl-5-O-(methanesulfonyl)-4-C-[[(methanesulfonyl)oxy]methyl]-1,2-O-isopropylidene-β-L-threo-pentofuranose 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 72261-44-0 1,2-O-isopropylidene-3-O-benzyl-4-C-(hydroxymethyl)-β-L-threo-pento-1,4-furanose 
• 894430-44-5 (1S,3R,4S,7R)-7-benzyloxy-1-hydroxymethyl-3-(thymin-1-yl)-5-trifluoroacetyl-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-43-4 (1S,3R,4S,7R)-7-benzyloxy-1-methanesulfonoxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-45-6 (1S,3R,4S,7R)-7-benzyloxy-1-hydroxymethyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-41-2 1-O-acetyl-2-azido-3-O-benzyl-2-deoxy-5-O-methanesulfonyl-4-C-methanesulfonoxymethyl-α,β-L-erythro-pentofuranose 
• 894430-40-1 methyl 2-azido-3-O-benzyl-2-deoxy-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-α,β-L-erythro-pentofuranoside 

Downstream Products

• 1357172-58-7 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-(perylen-3-yl)methyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1061578-72-0 (1S,3R,4S,7R)-5-acetyl-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1061578-69-5 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-5-ethyl-7-hydroxy-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 952723-71-6 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-[2-(pyren-1-yl)acetyl]-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1061578-75-3 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-(pyren-1-yl)carbonyl-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1061578-80-0 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-5-[4-(pyren-1-yl)butanoyl]-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 894430-48-9 (1S,3R,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-5-(9'-fluorenylmethoxycarbonyl)-7-hydroxy-3-(thymin-1-yl)-2-oxa-5-azabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

Synthesis and hybridization studies of 2′-amino-α-L-LNA and tetracyclic "locked LNA"

A convergent route to a new class of locked nucleic acids, i.e., 2′-amino-α-L-LNA, has been developed. The optimized synthetic route to the corresponding phosphoramidite building block of thymine proceeds in 4% overall yield over 15 steps from the startin

Synthesis of a 2′-amino-α-L-LNA-T phosphoramidite

A convergent route to 2′-amino-α-L-LNA-T phosphoramidite building block 16 has been developed. Key steps include 1) introduction of a C2-azido group prior to nucleobase-coupling, 2) tandem Staudinger and intramolecular nucleophilic substitution reaction,