1062-09-5

Basic information

• Product Name: BetaMethasone Cyclic 17,21-(Ethyl Orthopropionate)
• Synonyms: BetaMethasone Cyclic 17,21-(Ethyl Orthopropionate);(11beta,16beta)-17,21-[(1-Ethoxypropylidene)bis(oxy)]-9-fluoro-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
• CAS NO: 1062-09-5
• Molecular Formula: C₂₇H₃₇FO₆
• Molecular Weight: 476.5774832
• Product Categories: Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 1062-09-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Dichloromethane, Methanol
• CAS DataBase Reference: BetaMethasone Cyclic 17,21-(Ethyl Orthopropionate)(CAS DataBase Reference)
• NIST Chemistry Reference: BetaMethasone Cyclic 17,21-(Ethyl Orthopropionate)(1062-09-5)
• EPA Substance Registry System: BetaMethasone Cyclic 17,21-(Ethyl Orthopropionate)(1062-09-5)

Safety Data

• Hazardous Substances Data: 1062-09-5(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Derivative of betamethasone 17-Propionate (B327015), a degradation product of Betamethasone. Glucocorticoid.

Upstream product

• 378-44-9 betamethasone 
• 115-80-0 Triethyl orthopropionate 

Downstream Products

• 5534-13-4 Betamethasone propionate 
• 25122-46-7 clobetasol-17-propionate 

Relevant articles and documents

Preparation method of betamethasone 17 alpha-propionate

The invention provides a preparation method of betamethasone 17 alpha-propionate. According to the preparation method, betamethasone is subjected to a reaction with triethyl orthopropionate, the reaction is performed in a tetrahydrofuran solvent, further, p-toluenesulfonic acid is adopted as a catalyst, after the reaction is finished, an aluminum trichloride solution is dropwise added to the samesolvent system directly without discharging, a thermal insulation reaction is performed after the solution is dropwise added, and betamethasone 17 alpha-propionate is obtained with a post-treatment process. According to the preparation method of betamethasone 17 alpha-propionate, preparation process is simplified, yield is increased and purity is improved while the problem that dioxane, dimethylformamide or another solvent is adopted as the reaction solvent of betamethasone 17 alpha-propionate is solved.