1062174-70-2

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 141-43-5 ethanolamine 
• 153765-10-7 2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethanamine 
• 59795-45-8 phenanthrene-3,6-dicarboxylic acid 
• 181509-97-7 dimethyl phenanthrene-3,6-dicarboxylate 

Relevant academic research and scientific papers

Phenanthrene-derived DNA hairpin mimics

Self-complementary oligodeoxynucleotides containing 3,6-disubstituted phenanthrenes adopt highly stable, hairpin-like structures. The thermodynamic stability of the hairpin mimics depends on the overall length of the phenanthrene building block. Hairpin loops composed of a phenanthrene-3,6-dicarboxamide and ethylene linkers were found to be optimal. The hairpin mimics are more stable than the analogous hairpins containing either a dT4 or dA4 tetraloop. Model studies indicate that the thermodynamic stability of the hairpin mimics is primarily due to aromatic stacking of the phenanthrene-3,6-dicarboxamide onto the adjoining base pair of the DNA duplex.

DNA containing non-nucleosidic phenanthrene building blocks with asymmetrical linkers

The synthesis and hybridization properties of oligonucleotides containing phenanthrene building blocks with non-nucleosidic linkers of different length are described. It was found that the length of the linkers, as well as the combination of unequal linke