106276-04-4 Usage
General Description
The chemical [2-(2-morpholinoethoxy)phenyl]methanol, commonly known as MPEP, is a selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5) that is used in research to study the role of mGluR5 in various neurological and psychiatric disorders. It is a white solid with a molecular weight of 258.3 g/mol and a melting point of 140-141°C. MPEP has been found to have potential therapeutic applications in the treatment of conditions such as fragile X syndrome, Parkinson's disease, and drug addiction. Its mechanism of action involves inhibiting the binding of glutamate to mGluR5, thus modulating the glutamate signaling pathway in the brain.
Check Digit Verification of cas no
The CAS Registry Mumber 106276-04-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,2,7 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 106276-04:
(8*1)+(7*0)+(6*6)+(5*2)+(4*7)+(3*6)+(2*0)+(1*4)=104
104 % 10 = 4
So 106276-04-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H19NO3/c15-11-12-3-1-2-4-13(12)17-10-7-14-5-8-16-9-6-14/h1-4,15H,5-11H2
106276-04-4Relevant articles and documents
5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS
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, (2008/06/13)
The present invention relates to certain 5-aralkylsulfonyl-3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives that inhibit kinases, in particular met kinase. Pharmaceutical compositions comprising these compounds, methods of treating diseases mediated by kinases utilizing pharmaceutical compositions comprising these compounds, and methods of preparing them are also disclosed.
