106328-28-3Relevant articles and documents
Aryl derivatives
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, (2008/06/13)
Novel compounds of formula (I) wherein: k, p and q are independently 0 or 1; Ar represents either: (i) naphthyl, tetrahydronaphthyl, pyridyl or (ii) phenyl, optionally substituted, L is selected from --(CH2)r -- (where r is 1-4), --O--, --CH2 O--, --CH2 S--, --OCH2 --, --CONH--, --NHCO--, --CO-- and --CH2 NH--, and, Ar' represents phenylene, thienylene or pyridylene optionally substituted, X represents oxygen, sulphur or carbonyl, Y is C1-10 alkylene or C1-10 alkenylene; Q represents a non-cyclic moiety selected from groups of formula STR1 in which one of m and n is 0 and the other is 1, R1 and R2 is selected from hydrogen, C1-4 alkyl, amino, C1-4 alkylamino, di-C1-4 alkylamino, C5-7 cycloalkylamino, C5-7 cycloalkyl (C1-4 alkyl) amino, anilino, N-C1-4 alkylanilino or Q represents a cyclic moiety selected from 1-hydroxy-1,3-dihydroimidazol-2-one and groups of formula STR2 in which Z represents a C2-5 alkylene chain in which one of the carbon atoms may be replaced by a hetero atom; and salts thereof.
Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis
Summers,Gunn,Martin,Martin,Mazdiyasni,Stewart,Young,Bouska,Dyer,Brooks,Carter
, p. 1960 - 1964 (2007/10/02)
The nature of the carbonyl and nitrogen substituents of hydroxamic acids has a major influence on the biological profile of these compounds. Hydroxamates with small groups such as methyl appended to the carbonyl and relatively large nitrogen substituents
