106328-90-9Relevant articles and documents
Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators
Bridges, Thomas M.,Kennedy, J. Phillip,Hopkins, Corey R.,Conn, P. Jeffrey,Lindsley, Craig W.
scheme or table, p. 5617 - 5622 (2010/11/05)
This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M5-preferring positive allosteric modulator (PAM), discovered through analog work around VU0119498, a pan Gq mAChR M1, M3, M5 PAM. An iterative parallel synthesis approach was employed to incorporate basic heterocycles to improve physiochemical properties.