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[4-(PYRID-2-YLOXY)PHENYL]METHANOL, with the molecular formula C13H11NO2, is a white solid chemical compound that is soluble in organic solvents. It features a unique structure comprising a phenyl ring and a pyridine ring connected by an oxygen atom, which endows it with versatility in organic synthesis. [4-(PYRID-2-YLOXY)PHENYL]METHANOL has a melting point of 83-87°C and serves as a valuable building block for the preparation of pharmaceuticals and agrochemicals, as well as a reagent in chemical reactions for forming carbon-carbon and carbon-heteroatom bonds.

194017-70-4

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194017-70-4 Usage

Uses

Used in Organic Synthesis:
[4-(PYRID-2-YLOXY)PHENYL]METHANOL is used as a building block for the synthesis of various organic molecules due to its unique structure that facilitates the formation of carbon-carbon and carbon-heteroatom bonds.
Used in Pharmaceutical Industry:
[4-(PYRID-2-YLOXY)PHENYL]METHANOL is used as a precursor in the preparation of pharmaceuticals, contributing to the development of new drugs by providing a versatile starting material for medicinal chemists.
Used in Agrochemical Industry:
[4-(PYRID-2-YLOXY)PHENYL]METHANOL is used as a component in the synthesis of agrochemicals, playing a role in the creation of pesticides and other agricultural products to improve crop protection and yield.
Used as a Reagent in Chemical Reactions:
[4-(PYRID-2-YLOXY)PHENYL]METHANOL is utilized as a reagent in chemical reactions, particularly for the formation of carbon-carbon and carbon-heteroatom bonds, which are crucial in the synthesis of complex organic compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 194017-70-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,4,0,1 and 7 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 194017-70:
(8*1)+(7*9)+(6*4)+(5*0)+(4*1)+(3*7)+(2*7)+(1*0)=134
134 % 10 = 4
So 194017-70-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H11NO2/c14-9-10-4-6-11(7-5-10)15-12-3-1-2-8-13-12/h1-8,14H,9H2

194017-70-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-pyridin-2-yloxyphenyl)methanol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:194017-70-4 SDS

194017-70-4Relevant articles and documents

Discovery of Novel Cytochrome bc1 Complex Inhibitor Based on Natural Product Neopeltolide

Chen, Qiong,Chen, Tao,Gao, Meng-Qi,Wang, Yu-Xia,Yang, Guang-Fu,Zhang, Rui,Zhu, Xiao-Lei

, p. 263 - 268 (2022/05/12)

Background: Natural products (NPs) are important sources for the design of new drugs and agrochemicals. Neopeltolide, a marine NP, has been identified as a potent Qo-site inhibitor of cytochrome bc1 complex. Methods: In this study, a series of neopeltolide derivatives was designed and synthesized by the simplification of its 14-membered macrolactone ring with a diphenyl ether fragment. The enzymatic inhibition bioassays and mycelium growth inhibition experiments against a range of fungi were performed to determine their fungicidal activities. Results: The derivatives have potent activity against the porcine bc1 complex. Compound 8q showed the best activity with an IC50 value of 24.41 nM, which was 8-fold more effective than that of positive control azoxystrobin. Compound 8a exhibited a 100% inhibitory rate against Zymoseptoria tritici and Alternaria solani at a 20 mg/L dose. Conclusion: Computational results indicated that compounds with suitable physicochemical properties, as well as those forming a hydrogen bond with His161, would have good fungicidal activity. These data could be useful for the design of bc1 complex inhibitors in the future.

Ir-Catalyzed Ligand-Free Directed C-H Borylation of Arenes and Pharmaceuticals: Detailed Mechanistic Understanding

Mahamudul Hassan, Mirja Md,Mondal, Biplab,Singh, Sukriti,Haldar, Chabush,Chaturvedi, Jagriti,Bisht, Ranjana,Sunoj, Raghavan B.,Chattopadhyay, Buddhadeb

, p. 4360 - 4375 (2022/03/16)

An efficient method for Ir-catalyzed ligand free ortho borylation of arenes (such as, 2-phenoxypyridines, 2-anilinopyridines, benzylamines, benzylpiperazines, benzylmorpholines, benzylpyrrolidine, benzylpiperidines, benzylazepanes, α-amino acid derivatives, aminophenylethane derivatives, and other important scaffolds) and pharmaceuticals has been developed. The reaction underwent via an interesting mechanistic pathway, as revealed by the detailed mechanistic investigations by using kinetic isotope studies and DFT calculations. The catalytic cycle is found to involve the intermediacy of an Ir-boryl complex where the substrate C-H activation is the turnover determining step, intriguingly without any appreciable primary KIE. The method displays a broad range of substrate scope and functional group tolerance. Numerous late-stage borylation of various important molecules and drugs were achieved using this developed strategy. The borylated compounds were further converted into more valuable functionalities. Moreover, utilizing the benefit of the B-N intramolecular interaction of the mono borylated compounds, an operationally simple method has been developed for the selective diborylation of 2-phenoxypyridines and numerous functionalized arenes. Furthermore, the synthetic utility has been showcased with the removal of the pyridyl directing group from the borylated product to achieve ortho borylated phenol along with the ipso-borylation for the preparation of 1,2-diborylated benzene.

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators

Bridges, Thomas M.,Kennedy, J. Phillip,Hopkins, Corey R.,Conn, P. Jeffrey,Lindsley, Craig W.

scheme or table, p. 5617 - 5622 (2010/11/05)

This Letter describes a chemical lead optimization campaign directed at VU0238429, the first M5-preferring positive allosteric modulator (PAM), discovered through analog work around VU0119498, a pan Gq mAChR M1, M3, M5 PAM. An iterative parallel synthesis approach was employed to incorporate basic heterocycles to improve physiochemical properties.

N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL) PIPERIDINES AND PYRIDINES

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Page/Page column 56, (2010/02/07)

It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independ

SUBSTITUTED CARBOXYLIC ACID DERIVATIVES

-

Page/Page column 25, (2010/11/29)

The invention provides novel substituted carboxylic acid derivatives that bind to receptor as ligands of human peroxisome proliferator-activated receptor (PPAR) to activate it and exhibit potent triglyceride-lowering action, cholesterol-lowering action an

Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines

-

, (2008/06/13)

Compounds of the following structure are disclosed as effective insecticides: in which: A and B are independently lower alkyl; U is lower alkylidene, lower alkenylidene, or CH—Z, where Z is hydrogen, lower alkyl, lower cycloalkyl, or phenyl; R is phenyl o

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