106345-32-8

Basic information

• Product Name: 1H-Indole, 2-phenyl-3-(phenylthio)-
• CAS NO: 106345-32-8
• Molecular Formula: C20H15NS
• Molecular Weight: 301.412
• Mol File: 106345-32-8.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 2-phenyl-3-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2-phenyl-3-(phenylthio)-(106345-32-8)
• EPA Substance Registry System: 1H-Indole, 2-phenyl-3-(phenylthio)-(106345-32-8)

Safety Data

• Hazardous Substances Data: 106345-32-8(Hazardous Substances Data)

Upstream product

• 76794-16-6 3-chloro-2-phenyl-1H-indole 
• 882-33-7 diphenyldisulfane 
• 948-65-2 2-phenyl-indole 
• 194720-38-2 2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate 
• 13141-38-3 2-phenylethynylaniline 
• 873-55-2 sodium benzenesulfonate 
• 73038-47-8 2-[(phenylthio)methyl]-1-iodobenzene 
• 100-47-0 benzonitrile 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 5883-81-8 2-anilinoacetophenone 
• 62-53-3 aniline 
• 32119-53-2 N-methyl-N-phenacylaniline 
• 4831-18-9 N-phenacyl-p-toluidine 
• 2727-71-1 N-(2-bromophenyl)-2,2,2-trifluoroacetamide 

Downstream Products

• 1613218-93-1 C₂₇H₂₁NS 
• 82946-84-7 1-methyl-2-phenyl-3-(phenylthio)-1H-indole 
• 948-65-2 2-phenyl-indole 

Relevant articles and documents

Sulfanyl radical addition to alkynyl azides: An insight into vinyl radical cyclization onto the azido function

5-Exo-Cyclization of 2-sulfanylvinyl radicals 16 and 21 is a fast process which prevents intramolecular addition to the sulfanyl aromatic ring and hydrogen abstraction. In contrast, the 2-sulfanylvinyl radicals 3 and 9 are reluctant to add to their alipha

Aniline-initiated and Br?nsted acid-catalyzed one-pot reaction toward 2-aryl-3-sulfenylindoles by using α-aminocarbonyl compounds and primary amines with RSSR

A highly novel method of direct synthesis of 2-aryl-3-sulfenylindoles in moderate to good yields was developed via one-pot tandem reaction of readily available α-aminocarbonyl compounds and catalytic amount of benzenamines with RSSR.

Synthesis of Polysubstituted 3-Chalcogenated Indoles through Copper(I) Iodide-Catalyzed Three-Component Domino Reactions

Polysubstituted 3-chalcogenated indoles were synthesized by a three-component, one-pot, domino reaction of a N -(2-bromophenyl)trifluoroacetamide, a 1-alkyne, a disulfides or diselenides, CuI, and proline in DMF. In this process, tandem Sonogashira coupling, N-cyclization, and sulfenyl/selenyl electrophilic substitution occurred sequentially and smoothly to form the anticipated products in good to excellent yields (20 examples; 65-96%). Notably, no palladium catalyst was used in this catalytic system, supporting its cost effectiveness and potential industrial application.

Metal Free Mono- and 2,3-Bis-sulfenylation of Indoles in Water with Sodium Sulfinates as a Sulfur Source

An iodine-PPh3 mediated sulfenylation of indoles in water with stable and odorless sodium sulfinates as the sulfur source is described. The reaction could afford monosulfenylated indoles in moderate to excellent yields under metal free conditions. Moreover, double C—H sulfenylation of indoles at 2- and 3-positions has also been achieved by using excess sodium sulfinates under the optimized reaction conditions.