82946-84-7

Basic information

• Product Name: 1-methyl-2-phenyl-3-(phenylthio)-1H-indole
• Synonyms: 1-methyl-2-phenyl-3-(phenylthio)-1H-indole
• CAS NO: 82946-84-7
• Molecular Weight: 315.439
• Mol File: 82946-84-7.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 1-methyl-2-phenyl-3-(phenylthio)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-phenyl-3-(phenylthio)-1H-indole(82946-84-7)
• EPA Substance Registry System: 1-methyl-2-phenyl-3-(phenylthio)-1H-indole(82946-84-7)

Safety Data

• Hazardous Substances Data: 82946-84-7(Hazardous Substances Data)

Upstream product

• 82665-92-7 3-chloro-1-methyl-2-phenyl-1H-indole 
• 882-33-7 diphenyldisulfane 
• 3558-24-5 1-methyl-2-phenyl-1H-indole 
• 194720-38-2 2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate 
• 170956-92-0 N-methyl-2-(2-phenylethynyl)aniline 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 98-80-6 phenylboronic acid 
• 77-78-1 dimethyl sulfate 
• 106345-32-8 2‐phenyl‐3‐(phenylthio)‐1H‐indole 
• 948-65-2 2-phenyl-indole 
• 14204-27-4 N-phenylthiophthalimide 
• 54655-08-2 N,N-dimethyl-2-(2-phenylethynyl)aniline 
• 1357475-93-4 C₂₂H₁₇NO 
• 931-59-9 benzenesulfenyl chloride 

Relevant articles and documents

Palladium-catalyzed three-component cascade arylthiolation with aryldiazonium salts asS-arylation sources

A novel and efficient palladium-catalyzed three-component cascade cyclization/arylthiolation has been developed for the assembly of diverse 3-sulfenylindole and 3-sulfenylbenzofuran derivatives from 2-alkynylamines and 2-alkynylphenols, aryldiazonium salts, and Na2S2O3under aerobic conditions with PEG-200 as an environmentally benign medium. The current study features exceptional functional group tolerance without additional ligands, oxidants or silver salts, and eco-friendly mild reaction conditions. The ionic liquid [C2OHmim]Cl plays a crucial role in this protocol as an environmentally friendly additive. Notably, this procedure represents the first example of the use of aryldiazonium salts as directS-arylation sources in this type of chemical transformation.

Direct, Metal-free C(sp2)?H Chalcogenation of Indoles and Imidazopyridines with Dichalcogenides Catalysed by KIO3

Herein, we report a greener protocol for the synthesis of 3-Se/S-indoles and imidazo[1,2-a]pyridines through direct C(sp2)?H bond chalcogenation of heteroarenes with half molar equivalents of different dichalcogenides, using KIO3 as a non-toxic, easy-to-handle catalyst and a stoichiometric amount of glycerol. The reaction features are high yields, based on atom economy, easy performance on gram-scale, metal- and solvent-free conditions as well as applicability to different types of N-heteroarenes.

NH4I-catalyzed chalcogen(S/Se)-functionalization of 5-membered N-heteroaryls under metal-free conditions

Herein, we described the NH4I-catalyzed C–H bond chalcogenation of N-heteroaryls in the presence of a minimum amount of DMSO/H2O/acetic acid as additives (2.5/2.5/1 M equiv., respectively), under metal-free conditions. Under optimized conditions, a wide variety of sulfenyl/selenyl imidazo[1,2-α]pyridines were prepared in very good yields. Moreover, the present approach was also highly efficient for the chalcogenation of different 5-membered N-heteroaryls, e.g., indole, imidazothiazole, indazole and imidazopyrimidine derivatives.