106345-99-7

Upstream product

• 61018-80-2 (4-hydroxy-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[e][1,2]thiazin-3-yl)-phenyl-methanone 
• 74-88-4 methyl iodide 
• 128-44-9 saccharin sodium salt 
• 15246-95-4 1,1-dioxo-2-(2-oxo-2-phenyl-ethyl)-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one 
• 77-78-1 dimethyl sulfate 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 1229567-37-6 C₁₇H₁₂F₃NO₆S₂ 
• 1217297-48-7 C₂₄H₁₉NO₅S 
• 17833-87-3 1,4-dihydro-4-methyl-3-phenylpyrazolo<4,3-c>-<1,2>-benzothiazine 5,5-dioxide 
• 1499151-86-8 methyl 2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetate 
• 1499151-88-0 ethyl 2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetate 
• 1499151-89-1 2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide 
• 1499151-39-1 N'-(4-bromobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide 
• 1499151-41-5 N'-(2,6-dichlorobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide 
• 1499151-43-7 N'-(4-chlorobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide 
• 1499151-45-9 N'-(4-(dimethylamino)benzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo [4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide 
• 1499151-47-1 2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)-N'-(2-nitrobenzylidene)acetohydrazide 
• 1499151-49-3 2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)-N'-(3-nitrobenzylidene)acetohydrazide 
• 1499151-52-8 N'-(4-(diethylamino)benzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide 
• 1499151-53-9 N'-(2,4-dichlorobenzylidene)-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazide 

Relevant academic research and scientific papers

Studies on synthesis of novel triazole tagged pyrazole fused naphthalene 5-thiazine-5,5-dioxide derivatives, their antimicrobial, and antioxidant activity

A series of novel triazole tagged pyrazole fused naphthalene-5-thiazine-5, 5-dioxide derivatives 8 and 9 were synthesized starting from sodium salt of saccharin 1. The structure of each intermediate and products was established on the basis of spectroscop

Discovery of (2-benzoylethen-1-ol)-containing 1,2-benzothiazine derivatives as novel 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibiting-based herbicide lead compounds

A series of (2-benzoylethen-1-ol)-containing benzothiazine derivatives was synthesized, and their herbicidal activities were first evaluated. The bioassay results indicated that some of 3-benzoyl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide derivatives displayed good herbicidal activity in greenhouse testing, especially, compound 4w had good pre-emergent herbicidal activities against Brassica campestris, Amaranthus retroflexus and Echinochloa crusgalli even at a dosage of 187.5 g ha-1. More importantly, compound 4w displayed significant inhibitory activity against Arabidopsis thaliana HPPD and was identified as the most potent candidate with IC50 value of 0.48 μM, which is better than the commercial herbicide sulctrione (IC50 = 0.53 μM) and comparable with the commercial herbicide mesotrione (IC50 = 0.25 μM). The structure-activity relationships was studied and provided some useful information for improving herbicidal activity. The present work indicated that (2-benzoylethen-1-ol)-containing 1,2-benzothiazine motif could be a potential lead structure for further development of novel HPPD inhibiting-based herbicides.

Synthesis, molecular docking and antiviral screening of novel N'-substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e]pyrazolo[4, 3-c][1,2]thiazin-1(4H)-yl)acetohydrazides

N'-Substitutedbenzylidene-2-(4-methyl-5,5-dioxido-3-phenylbenzo[e] pyrazolo[4,3-c][1,2]thiazin-1(4H)-yl)acetohydrazides (7a-u) were synthesized through a multistep reaction. The final compounds were screened for anti-HIV-1 and cytotoxic activities. Among

Discovery of cyclicsulfonamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors

A new series of cyclic sulfonamide derivatives was synthesized and evaluated for their ability to inhibit 11β-HSD1. Cyclic sulfonamides with phenylacetyl substituents at the 2-position showed nanomolar inhibitory activities. Among them, compound 4e exhibited a good in vitro inhibitory activity and selectivity toward human 11β-HSD2.