106352-19-6

Basic information

• Product Name: 2-METHYLENE-CYCLOPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER
• Synonyms: 2-METHYLENE-CYCLOPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER;Diethyl 2-Methylenecyclopropane-1,1-dicarboxylate
• CAS NO: 106352-19-6
• Molecular Formula: C₁₀H₁₄O₄
• Molecular Weight: 198.21576
• Mol File: 106352-19-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 218.3°C at 760 mmHg
• Flash Point: 96.7°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.127mmHg at 25°C
• Refractive Index: 1.47
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-METHYLENE-CYCLOPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLENE-CYCLOPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER(106352-19-6)
• EPA Substance Registry System: 2-METHYLENE-CYCLOPROPANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER(106352-19-6)

Safety Data

• Hazardous Substances Data: 106352-19-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H14O4/c1-4-13-8(11)10(6-7(10)3)9(12)14-5-2/h3-6H2,1-2H3

Upstream product

• 13830-91-6 diethyl bromoisopropylidenemalonate 
• 865-47-4 potassium tert-butylate 
• 75-65-0 tert-butyl alcohol 
• 6802-75-1 diethyl isopropylidenemalonate 
• 167401-82-3 diethyl 1-(phenylselenyl)methylcyclopropane-2,2-dicarboxylate 
• 144296-42-4 2-iodomethyl-cyclopropane-1,1-dicarboxylic acid diethyl ester 
• 841275-59-0 diethyl 1-(phenylselenyl)methylcyclopropane-2,2-dicarboxylate selenium oxide 

Relevant articles and documents

Catalytic [3 + 2] Cycloaddition through Ring Cleavage of Simple Cyclopropanes with Isocyanates

The catalytic synthesis of γ-butyrolactams was established via [3 + 2]-cycloaddition of cyclopropanes with isocyanates. An organotin iodide ate complex, MgBr+[Bu2SnBrI2]-, was employed as an effective catalyst. Simple cyclopropanes that lack aryl or vinyl substituents were useful precursors. Even acyl cyclopropanes were applicable. The hybrid characteristics of a tin complex, acidic MgBr+ with nucleophilic tin iodide, was responsible for the catalytic reaction.

Catalytic Annulation of Diethyl Methylenecyclopropane-1,1-dicarboxylate with 1,1-Dicyanoalkenes

The catalytic annulation of methylenecyclopropane 1 with 1,1-dicyanoalkenes 2 using a Mg-Sn catalytic system was developed. Selective formation of cyclopentylidenemalonates 3 and spiro[2,3]hexane-1,1-dicarboxylates 4 was accomplished via the choice of a proper solvent and an effective catalytic system.

Diastereoselective Synthesis of Spiro[2.3]hexanes from Methylenecyclopropane and Cyanoalkenes Catalyzed by a Tin-Ate Complex

A diastereoselective synthesis of spiro[2.3]hexane catalyzed by Sn and Mg halides was developed from a combination of methylenecyclopropane and cyanoalkene bearing an ester group. The selectivity was affected by the size of the halogen in the catalyst and

Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl) methylenecyclopropane analogues of purine nucleosides: Synthesis and antiviral activity

Phenylmethylphosphor-L-alaninate pronucleotides 7a, 7b, 8a, and 8b, cyclic phosphates 10a and 10b, and phosphates 11a and 11b derived from 2,2-bis(hydroxymethyl)methylenecyclopropane analogues 1a, 1b, 2a, and 2b were synthesized and evaluated for their an