106359-69-7

Basic information

• Product Name: 4-(2-Hydroxynaphthalen-1-yl)benzoic acid
• Synonyms: 4-(2-Hydroxynaphthalen-1-yl)benzoic acid;4-(2-Methylnaphthalen-1-yl)benzoic acid;4-(4-(Dimethylamino)naphthalen-1-yl)benzoic acid;4-(4-Aminonaphthalen-1-yl)benzoic acid;4-(4-Fluoronaphthalen-1-yl)benzoic acid
• CAS NO: 106359-69-7
• Molecular Formula: C₁₇H₁₂O₂
• Molecular Weight: 248.28
• Mol File: 106359-69-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-Hydroxynaphthalen-1-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Hydroxynaphthalen-1-yl)benzoic acid(106359-69-7)
• EPA Substance Registry System: 4-(2-Hydroxynaphthalen-1-yl)benzoic acid(106359-69-7)

Safety Data

• Hazardous Substances Data: 106359-69-7(Hazardous Substances Data)

Usage

General Description

4-(2-Hydroxynaphthalen-1-yl)benzoic acid, also known as HNB, is a chemical compound with the molecular formula C18H12O3. It is a derivative of benzoic acid and contains a hydroxyl group attached to a naphthalene ring. HNB is often used as a fluorescent probe in biological research to study protein-ligand interactions and binding affinities. It has also been found to have potential anti-inflammatory and antioxidant properties, making it a promising candidate for the development of new pharmaceuticals. Additionally, HNB has been investigated for its potential use in organic light-emitting diodes (OLEDs) and other optoelectronic applications due to its fluorescence properties. Overall, 4-(2-Hydroxynaphthalen-1-yl)benzoic acid has a variety of potential uses in the fields of biology, medicine, and materials science.

Upstream product

• 13922-41-3 1-Naphthylboronic acid 
• 1711-02-0 4-iodobenzoic acid chloride 
• 586-76-5 4-Bromobenzoic acid 
• 7029-32-5 dinaphthalen-1-ylzinc 
• 90-11-9 1-Bromonaphthalene 
• 14047-29-1 4-carboxyphenylboronic acid 
• 456-22-4 4-Fluorobenzoic acid 
• 703-55-9 1-naphthylmagnesiumbromide 
• 619-58-9 4-iodobenzoic acid 
• 27331-34-6 1-(4-methylphenyl)naphthalene 
• 619-44-3 methyl 4-iodobenzoate 
• 229467-26-9 4-naphthalene-1-ylbenzoic acid methyl ester 

Downstream Products

• 106359-61-9 N-hydroxy-4-(naphthalene-1-yl)benzamide 

Relevant articles and documents

Cobalt-Catalyzed Biaryl Couplings via C-F Bond Activation in the Absence of Phosphine or NHC Ligands

A highly general and selective Co-catalyzed biaryl coupling through C-F cleavage under phosphine or NHC-free conditions was described. A broad range of aryl fluorides including unactivated fluorides as well as those with sensitive functionalities could couple with various Ti(OEt)4-mediated aryl Grignard reagents with high selectivity under the catalysis of CoCl2/DMPU. Importantly, selective C-F bond activation couplings between two types of fluorines (difluorinated aromatics and on two different coupling partners) and in the presence of C-Cl or C-Br bonds could also be achieved.

Selective Co/Ti cooperatively catalyzed biaryl couplings of aryl halides with aryl metal reagents

Various aryl bromides or chlorides, including those bearing a free COOH, OH, CONHR, and SO2NHR group, coupled with aryl magnesium or lithium reagents in the presence of 7.5 mol % CoCl2/15 mol % PBu3 and substoichiometric Ti(OEt)4 (40 mol % to ArM) at room temperature in high yields with high chemo- and regioslectivity. This simple reaction represents the first example of Co/Ti cooperative catalysis which plays a key role in suppressing undesired homocouplings.

Exploring the selectivity of the Suzuki-Miyaura cross-coupling reaction in the synthesis of arylnaphthalenes

A series of 1-arylnaphthalenes and 1,8-diarylnaphthalenes were synthesized by the Suzuki-Miyaura cross-coupling methodology showing significant differentiation in the yields and selectivity between aryl rings with electron donating (higher yields), and el