106359-69-7

Usage

Uses

Used in Biological Research:
4-(2-Hydroxynaphthalen-1-yl)benzoic acid is used as a fluorescent probe for studying protein-ligand interactions and binding affinities. Its fluorescence properties allow for the visualization and analysis of molecular interactions in biological systems.
Used in Pharmaceutical Development:
HNB is used as a potential anti-inflammatory and antioxidant agent in the development of new pharmaceuticals. Its promising properties suggest potential therapeutic applications in treating inflammation and oxidative stress-related conditions.
Used in Organic Light-Emitting Diodes (OLEDs):
4-(2-Hydroxynaphthalen-1-yl)benzoic acid is used as a component in OLEDs and other optoelectronic applications due to its fluorescence properties. Its ability to emit light upon electrical stimulation makes it a valuable material in the design and fabrication of advanced display and lighting technologies.
Used in Materials Science:
HNB is utilized in the field of materials science for its potential applications in the development of new materials with unique optical, electronic, and structural properties. Its fluorescent characteristics can contribute to the creation of innovative materials for various industries.

Upstream product

• 229467-26-9 4-naphthalene-1-ylbenzoic acid methyl ester 
• 13922-41-3 1-Naphthylboronic acid 
• 1711-02-0 4-iodobenzoic acid chloride 
• 90-11-9 1-Bromonaphthalene 
• 14047-29-1 4-carboxyphenylboronic acid 
• 619-58-9 4-iodobenzoic acid 
• 586-76-5 4-Bromobenzoic acid 
• 703-55-9 1-naphthylmagnesiumbromide 
• 456-22-4 4-Fluorobenzoic acid 
• 7029-32-5 dinaphthalen-1-ylzinc 
• 27331-34-6 1-(4-methylphenyl)naphthalene 
• 619-44-3 methyl 4-iodobenzoate 

Downstream Products

• 106359-61-9 N-hydroxy-4-(naphthalene-1-yl)benzamide 

Relevant academic research and scientific papers

Cobalt-Catalyzed Biaryl Couplings via C-F Bond Activation in the Absence of Phosphine or NHC Ligands

A highly general and selective Co-catalyzed biaryl coupling through C-F cleavage under phosphine or NHC-free conditions was described. A broad range of aryl fluorides including unactivated fluorides as well as those with sensitive functionalities could couple with various Ti(OEt)4-mediated aryl Grignard reagents with high selectivity under the catalysis of CoCl2/DMPU. Importantly, selective C-F bond activation couplings between two types of fluorines (difluorinated aromatics and on two different coupling partners) and in the presence of C-Cl or C-Br bonds could also be achieved.

WAVELENGTH CONVERSION MATERIAL FOR HIGHLY EFFICIENT DYE-SENSITIZED SOLAR CELL, AND PREPARATION METHOD THEREOF

Novel compounds represented by the present invention refers to formula 1 or formula 2, said novel compounds including wavelength change material, and including said wavelength change material relates to dye-sensitized solar cell.

Selective Co/Ti cooperatively catalyzed biaryl couplings of aryl halides with aryl metal reagents

Various aryl bromides or chlorides, including those bearing a free COOH, OH, CONHR, and SO2NHR group, coupled with aryl magnesium or lithium reagents in the presence of 7.5 mol % CoCl2/15 mol % PBu3 and substoichiometric Ti(OEt)4 (40 mol % to ArM) at room temperature in high yields with high chemo- and regioslectivity. This simple reaction represents the first example of Co/Ti cooperative catalysis which plays a key role in suppressing undesired homocouplings.

Synthesis, characterization and catalytic applications of palladium nanoparticle-cored dendrimers stabilized by metal-carbon bonds

The synthesis and characterization of four generations of palladium nanoparticle-cored Frechet-type dendrimers (Pd-Gn) possessing direct palladium-carbon bonds are reported. These core-shell materials have been synthesized by the simultaneous reduction of different generation diazodendrons and PdII in an organic medium. The resulting organic-inorganic hybrid materials were characterized by IR, NMR and UV/Vis spectroscopic techniques. The formation of nearly spherical particles of 2-4 nm diameter was confirmed by TEM studies. The efficiency of one member of this series, Pd-G 1, in catalysing important C-C bond-forming reactions such as Suzuki, Stille and Hiyama coupling reactions was investigated. The results clearly show that Pd-G1 can efficiently catalyse the cross-coupling of arylboronic acids, aryl stannanes and organosilicon compounds with differently substituted aryl halides in addition to efficiently catalysing hydrogenation reactions. The catalyst exhibited good recovery and recyclability in Suzuki coupling reactions. The study suggests that a single catalyst capable of catalysing several reactions can be designed. Palladium nanoparticle-cored dendrimers synthesized by the reduction of PdII in the presence of diazodendrons find use as efficient catalysts for different cross-coupling reactions with good recyclability.

Exploring the selectivity of the Suzuki-Miyaura cross-coupling reaction in the synthesis of arylnaphthalenes

A series of 1-arylnaphthalenes and 1,8-diarylnaphthalenes were synthesized by the Suzuki-Miyaura cross-coupling methodology showing significant differentiation in the yields and selectivity between aryl rings with electron donating (higher yields), and el

[Pd(Cl)2(P(NC5H10)(C6H 11)2)2] - A highly effective and extremely versatile palladium-based negishi catalyst that efficiently and reliably operates at low catalyst loadings

[Pd(Cl)2(P(NC5H10)-(C6H 11)2]2] (1) has been prepared in quantitative yield by reacting commercially available [Pd(cod)(Cl)2] (cod = cyclooctadiene) with readily prepared 1-(dicyclohexylphosphanyl)piperidine in toluene under N2 within a few minutes at room temperature. Complex 1 has proved to be an excellent Negishi catalyst, capable of quantitatively coupling a wide variety of electronically activated, non-activated, deactivated, sterically hindered, heterocyclic, and functionalized aryl bromides with various (also heterocyclic) arylzinc reagents, typically within a few minutes at 100°C in the presence of just 0.01 mol% of catalyst. Aryl bromides containing nitro, nitrile, ether, ester, hydroxy, carbonyl, and carboxyl groups, as well as acetais, lactones, amides, anilines, alkenes, carboxylic acids, acetic acids, and pyridines and pyrimidines, have been successfully used as coupling partners. Furthermore, electronic and steric variations are tolerated in both reaction partners. Experimental observations strongly indicate that a molecular mechanism is operative.

INHIBITORS FOR HDAC8

INHIBITORS FOR HDAC8 ABSTRACT OF THE DISCLOSURE This invention discloses a new HDAC inhibitor scaffold designed to exploit a unique sub-pocket of the HDAC8 active site. These compounds are based on inspection of HDAC8 crystal structures bound to various inhibitors, which showed that the HDAC8 active site is surprisingly malleable and can accommodate inhibitor structures that are distinct from the canonical "zinc-binding group-linker-cap group" structures of SAHA, TSA and similar HDAC inhibitors. Some of the new inhibitors based on this new scaffold are >100 fold selective for HDAC8 over other class I and class II HDACs with IC50 values 1μM against HDAC8. The present invention provides a new type of "linkerless" HDAC8 inhibitors and methods of treating a pathological condition using the same. Treatment of human cells with the new inhibitors of the present invention show a unique pattern of hyperacetylated proteins compared with the broad spectrum HDAC inhibitor TSA.

Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors

In this report, we describe new HDAC inhibitors designed to exploit a unique sub-pocket in the HDAC8 active site. These compounds were based on inspection of the available HDAC8 crystal structures bound to various inhibitors, which collectively show that the HDAC8 active site is unusually malleable and can accommodate inhibitor structures that are distinct from the canonical 'zinc binding group-linker-cap group' structures of SAHA, TSA, and similar HDAC inhibitors. Some inhibitors based on this new scaffold are >100-fold selective for HDAC8 over other class I and class II HDACs with IC50 values 1 μM against HDAC8. Furthermore, treatment of human cells with the inhibitors described here shows a unique pattern of hyperacetylated proteins compared with the broad-spectrum HDAC inhibitor TSA.

LUMINESCENT LANTHANIDE (III) -CHELATED DENDRITIC COMPLEXES HAVING LIGHT-HARVESTING EFFECT AND THEIR SYNTHETIC METHODS

The present invention relates to new organic luminescent complex compounds containing rare earth metal ions, and methods for preparing the same. The compounds have photophysical properties which are maximized by processes of absorbing and transferring art

Novel tricyclic diazepines tocolytic oxytocin receptor antagonists

This invention provides novel tricyclic diazepine compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including treatment of preterm labor, dysmenorrhea, endometritis, and for suppressing labor prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.