1063665-52-0Relevant articles and documents
Cyclopropanation of 5-methylene galactopyranosides by dihalo-, ethoxycarbonyl-, and unsubstituted carbenes
Corsaro, Antonino,Chiacchio, Maria Assunta,Pistarà, Venerando,Rescifina, Antonio,Vittorino, Elisa
, p. 8652 - 8658 (2008/12/21)
Cyclopropanation reactions of 6-deoxyhex-5-enopyranosides by methylene-zinc-iodide complex, dichlorocarbene, and rhodium ethoxycarbonyl complex addition afford optimum yields of the corresponding spirocyclopropanes. Surprisingly, a stereospecific spirocyclopropane derivative with the two halogens on the upper face of the 4-hydroxy substituent is obtained. To get more insight on the dichlorocarbene cyclopropanation process a computational study, based on DFT quantomechanic calculation was conducted.