106367-89-9

Upstream product

• 106367-88-8 6-(chloromethyl)-2,3-dimethoxybenzoic acid methyl ester 
• 121-45-9 phosphorous acid trimethyl ester 
• 106367-87-7 2,3-dimethoxy-6-(methoxymethyl)benzoic acid methyl ester 
• 3840-28-6 1,2-dimethoxy-4-(methoxymethyl)benzene 

Downstream Products

• 106367-90-2 methyl 3,4-dimethoxy-3',4'-methyldioxystilbene-2-carboxylate 
• 132628-85-4 methyl (E)-3,4-dimethoxy-2'-(1,3-dioxolan-2-yl)-4',5'-methylenedioxystilbene-2-carboxylate 
• 106367-91-3 3,4-dimethoxy-3',4'-methyldioxystilbene-2-carboxylic acid 
• 106367-92-4 3,4-dimethoxy-3',4'-methyldioxystilbene-2-(2,2-dimethoxyethyl)carboxamide 

Relevant academic research and scientific papers

A Simple Total Synthesis of the Isoindolobenzazepine Alkaloids Lennoxamine and Chilenamine

Lennoxamine (8) and chilenamine (9) have been synthesized from 3-(3,4-methylenedioxybenzylidene)-6,7-dimethoxyphthalide (1) in four and five high-yielding steps, respectively.The key step of the process is the cyclization, by intramolecular alkylation, of 3-(3,4-methylenedioxybenzyl)-6,7-dimethoxyphthalimidin-2-ylacetaldehyde dimethyl acetal (3) to 13,13a-dihydro-3,4-dimethoxy-10,11-methylenedioxyisoindolobenzazepin-5-one (7).Attempts to prepare (3) by base-catalysed cyclization of 3,4-dimethoxy-3',4'-methylenedioxystilbene-2-(2,2-dimethoxyethyl)carboxamide (15) were unsuccesful.