121-45-9 Usage
Chemical Properties
Trimethyl phosphite is a colorless liquid.
Distinctive pungent, pyridine-like odor. The Odor
Threshold is 0.0001 ppm.
Uses
Trimethyl phosphite has been used primarily as an intermediate in the manufacture of pesticides and the synthesis of organophosphate insecticides. It is also used as a fire retardants in the production of textiles, as an intermediate in the production of flame-retardant polymers for polyurethane foams, and as a catalyst.
Production Methods
Produced via a reaction between phosphorus trichloride and
methanol in the presence of a tertiary amine catalyst such as
diethylaniline.
Definition
ChEBI: Trimethyl phosphite is an organophosphorus compound that is phosphane in which the three hydrogens are replaced by methoxy groups. It is an alkylating agent used primarily in the synthesis of organophosphate compounds. It has a role as an alkylating agent.
Reactions
The reaction of trimethyl phosphite and dimethyl acetylenedicarboxylate in the presence of dimedone as the proton source/nucleophile leads to 2-(dimethoxy-phosphoryl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-succinic acid dimethyl ester in 91 % yields.It reacts with a catalytic amount of methyl iodide in the Arbuzov reaction to give dimethyl methylphosphonate:P(OCH3)3 → CH3P(O)(OCH3)2It is susceptible to oxidation to trimethyl phosphate.
General Description
Trimethyl phosphite appears as a clear colorless liquid with a strong foul odor. Flash point 99°F. Denser than water and insoluble in water. Vapors heavier than air. It is used in making pesticides, flame retardants and organophosphorous additives.
Air & Water Reactions
Highly flammable. Insoluble in water and denser than water. Slowly reacts with water to form phosphoric acid and corresponding organic alcohol. Trimethyl phosphite hydrolyzes in water to form dimethyl phosphite and methanol. The hydrolysis rate of trimethyl phosphite is expected to be similar to the hydrolysis rate of triethyl phosphite(SRC).
Reactivity Profile
As soon as Trimethyl phosphite contacted a small amount of magnesium perchlorate in a flask, there was a flash and an explosion that shattered the flask (Allison 1968).
Health Hazard
Trimethyl phosphite is a skin, eye, and mucous membrane irritant with low subacute inhalation toxicity. Its irritating action on rabbits’ skin was moderate to severe. The pure liquid instilled into the eyes can cause severe irritation and swelling, which can last for a few days. Chronic exposure to 300–600 ppm concentration in air produced lung inflammation and cataracts in mice. There was no acute inhalation toxicity observed in test animals. The oral and dermal toxicities were low.LD50 value, oral (rats): 1600 mg/kgTeratogenic effects showing gross abnormalities were observed in newborn rats when pregnant rats were dosed with high concentrations of trimethyl phosphite. The odor threshold for this compound was determined to be 0.0001 ppm (ACGIH 1986). The odor is irritating and pungent at high concentrations..
Fire Hazard
Special Hazards of Combustion Products: Toxic fumes of PO x
Safety Profile
Moderately toxic by
ingestion and skin contact. An experimental
teratogen. A severe skin and eye irritant.
Flammable liquid when exposed to heat,
flame, or oxidizers. To fight fire, use water,
foam, fog, CO2. Violent explosive reaction
on contact with magnesium perchlorate or
trimethyl platinum(IV) azide tetramer. When
heated to decomposition it emits toxic
fumes of POx. An intermediate in the
production of pesticides, fire retardants, and
organic phosphorus additives. See also
ESTERS.
Potential Exposure
Trimethyl phosphite is a flame
retardant, and used as an intermediate in the manufacture
of a number of pesticides, and organophosphorus
additives.
Carcinogenicity
Trimethyl phosphite was genotoxic in
mouse lymphoma assays but was not mutagenic
in various bacterial assays.
Shipping
UN2329 Trimethyl phosphite, Hazard Class: 3;
Labels: 3-Flammable liquid.
Purification Methods
Treat the phosphite with Na (to remove water and any dialkyl phosphonate), then decant and distil it with protection against moisture. It has also been treated with sodium wire for 24hours, then distilled in an inert atmosphere onto activated molecular sieves [Connor et al. J Chem Soc, Dalton Trans 511 1986]. It can be fractionally distilled using a spinning band column at high reflux ratio. It is a colourless liquid which is slowly hydrolysed by H2O. [Gillis et al. J Am Chem Soc 80 2999 1958, NMR: Callis et al. J Am Chem Soc 79 2719 1957, Kosolapoff Organophosphorus Compounds, Wiley p 203 1950, Beilstein 1 IV 1256.]
Incompatibilities
Vaor May form explosive mixture with
air. Incompatible with oxidizers (chlorates, nitrates, peroxides,
permanganates, perchlorates, chlorine, bromine, fluorine,
etc.); contact may cause fires or explosions. Violent
reaction with magnesium perchlorate.
Keep away from alkaline materials, strong bases, strong
acids, oxoacids, epoxides. Reacts (hydrolyzes) with water.
Incompatible with air, moisture.
Waste Disposal
Trimethyl phosphite may be burned in a chemical incinerator equipped with an afterburner and scrubber.
Check Digit Verification of cas no
The CAS Registry Mumber 121-45-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 121-45:
(5*1)+(4*2)+(3*1)+(2*4)+(1*5)=29
29 % 10 = 9
So 121-45-9 is a valid CAS Registry Number.
InChI:InChI=1/C3H9O4P/c1-5-8(4,6-2)7-3/h1-3H3
121-45-9Relevant articles and documents
Phosphorus halides complexes with 4-dimethylaminopyridine and N-methylimidazole
Bezgubenko,Pipko,Sinitsa
, p. 911 - 918 (2009)
Formation of complexes between phosphorus halides and 4- dimethylaminopyridine or N-methylimidazole was studied. The following phosphorus halides: trichloride, oxychloride, and sulfochloride, were found to form equilibrium mixtures of the complexes containing different numbers of the ligand molecules. Among the studied phosphorus halides only pentachloride and tribromide form stable complexes with a constant composition.
-
Bentrude
, p. 174 (1967)
-
Synthesis of tervalent phosphorus esters in biphasic system using potassium phosphate as unique solid base
Ilia, Gheorghe,Iliescu, Smaranda,Macarie, Lavinia,Popa, Adriana
, p. 360 - 364 (2008/09/20)
The synthesis of tervalent phosphorus esters continues to be a significant area of interest, much of it again directed toward the synthesis of phosphite ligands for metal-catalyzed reactions. Typically, they were obtained through esterification of the corresponding phosphorus chlorides with the appropriate alcohols in the presence of an amine. In this paper, we present a new method for the synthesis of tervalent phosphorus esters, not yet mentioned in the literature, when potassium phosphate, as a unique base, is used in liquid-solid system. Symmetrical and unsymmetrical phosphites were obtained with good yields (65%-80%) using this method. The compounds were characterized by 31P NMR spectroscopy.
2,4-diphosphoranediyl-l,3-diphosphetanes
Schroedel, Hans-Peter,Schmidpeter, Alfred
, p. 1519 - 1527 (2007/10/03)
The 1,3-dichloro- and 1,3-dibromo-substituted title compounds 5b, c result from the condensation of triphenylphosphonium-bis(trimethylsilyl)methylide 1 with PC13 and PBr3. The chloro derivative 5b undergoes a variety of single and double substitution reactions, of which some have merely been tested and others have been made preparative use of. The substitution of one chloride by an ylidyl, amino, phosphino, or metal carbonyl group is accompanied by the spontaneous dissociation of the other P-C1 bond to yield the 1,3-diphosphetenium chlorides 14/15, 19, 31 and 36, respectively. In other cases (9, 27, 32) dissociation can be achieved by means of a Lewis acid. Protonation of 5b occurs at the carbon ring members; methylation and formation of transition metal complexes occurs at a phosphorus ring member. PC13 degrades the four-membered ring of 5b or enlarges the ring to yield 3,5-diphosphoranediyl-l,2,4-triphospholane derivatives 39, 40, 42. Keywords: Phosphorus / Heterocycles / Phosphorus ylides / Phosphoranediyl and phosphonio substituants / P-C1 bond dissociation WILEY-VCH Verlag GmbH.
