106369-33-9Relevant academic research and scientific papers
Copper-Catalyzed Ring Expansion of Vinyl Aziridines under Mild Conditions
Tosi, Eleonora,Spielmann, Kim,De Figueiredo, Renata Marcia,Campagne, Jean-Marc
, p. 517 - 520 (2021/01/14)
Vinyl aziridines are versatile starting materials toward ring-expansion transformations. Such processes are widely used to give various medium or larger N-heterocycles of synthetic interest. This letter describes a copper-catalyzed ring expansion of vinyl aziridines to 3-pyrrolines by using a Cu(I) salt [(CuOTf) 2·toluene or Cu(MeCN) 4·PF 6]. In particular, this transformation occurs under mild conditions (THF, rt).
A NEW AND EFFECTIVE AMINOMETHYLATION BY THE USE OF N-(p-TOLUENESULFONYLMETHYL)-p-TOLUENESULFONAMIDE AS AN EQUIVALENT OF METHANIMINE. A CONVENIENT PREPARATION OF PYRROLE COMPOUNDS
Kinoshita, Hideki,Inomata, Katsuhiko,Hayashi, Masatoshi,Kondoh, Takeshi,Kotake, Hiroshi
, p. 1033 - 1036 (2007/10/02)
Readily available N-(p-toluenesulfonylmethyl)-p-toluenesulfonamide was treated with base to generate N-methylene-p-toluenesulfonamide which reacted with a variety of nucleophiles forming the corresponding N-tosyl-aminomethylated compounds in good yields.Furthermore, the N-tosyl-aminomethylated acetals thus obtained were converted into the corresponding N-tosylpyrroles with the aid of acid catalyst in excellent yields.
