1063693-74-2Relevant academic research and scientific papers
Regioselective cobalt-catalysed hydrovinylation for the synthesis of non-conjugated enones and 1,4-diketones
Kersten, Laura,Hilt, Gerhard
, p. 863 - 869 (2012/05/04)
The highly regioselective cobalt-catalysed 1,4-hydrovinylation of terminal alkenes with 2-trimethylsilyloxy-1,3-butadiene generates in a stereospecific fashion unsaturated E-configured silyl enol ether intermediates that are suitable for diastereoselective Mukaiyama-aldol reactions with bulky aliphatic aldehydes. The acidic hydrolysis of the enol ethers to γ,δ- unsaturated ketones followed by ozonolysis can be used for the synthesis of various 1,4-diketones and polycarbonyl derivatives. The 1,4-diketones and polycarbonyl derivatives were successfully tested for the synthesis of some mono- and bis-pyrrole derivatives. The γ,δ-unsaturated ketones are useful building blocks (e.g., in natural product synthesis) and can be generated in a one-pot procedure. Copyright
Regioselective nickel-catalyzed reductive couplings of enones and allenes
Li, Wei,Chen, Nan,Montgomery, John
supporting information; experimental part, p. 8712 - 8716 (2011/01/08)
Alkenes made easy: In a complement to coupling processes of terminal alkynes, the reductive coupling of enones and allenes provides access to conjugate addition products that possess a 1,1-disubstituted alkene (see scheme; cod=1,5-cyclooctadiene). The sol
Synthetic studies toward pectenotoxin 2. Part I. Stereocontrolled access to the C10-C22 fragment
Aho, Jatta E.,Salomaeki, Elina,Rissanen, Kari,Pihko, Petri M.
supporting information; experimental part, p. 4179 - 4182 (2009/05/27)
(Chemical Equation Presented) A highly stereocontrolled and efficient synthesis for a fully functionalized C10-C22 fragment of pectenotoxin 2 Is described using a convergent sequence involving a stereoselective methylation of β-hydroxyketone as a key step.
