1063733-08-3Relevant academic research and scientific papers
The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics
Pryde,Swain,Stupple,West,Marron,Markworth,Printzenhoff,Lin,Cox,Suzuki,McMurray,Waldron,Payne,Warmus,Chapman
, p. 1255 - 1267 (2017)
In this article, we describe the discovery of an aryl ether series of potent and selective Nav1.3 inhibitors. Based on structural analogy to a similar series of compounds we have previously shown bind to the domain IV voltage sensor region of Nav channels, we propose this series binds in the same location. We describe the development of this series from a published starting point, highlighting key selectivity and potency data, and several studies designed to validate Nav1.3 as a target for pain.
BENZAMIDE DERIVATIVES
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Page/Page column 72, (2010/04/27)
The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds in the treatment of pain.
