106380-46-5Relevant academic research and scientific papers
β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp 3)-H bonds using a palladium catalyst
Peng, Jing,Chen, Chao,Xi, Chanjuan
, p. 1383 - 1387 (2016/02/05)
An efficient method of selective β-arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp3)-H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp3)-C(sp2) bonds on a number of complex molecules derived from natural products and thus serves as a practical synthetic tool for direct late-stage C(sp3)-H functionalization.
Conducting moisture sensitive reactions under mechanochemical conditions
Waddell, Daniel C.,Clark, Tammara D.,MacK, James
scheme or table, p. 4510 - 4513 (2012/10/07)
Dry organic solvents are used for various organic reactions that employ moisture sensitive reagents. The processes to dry these solvents are hazardous and costly. Setting up reactions in an open atmosphere while using moisture sensitive reagents has little to no effect on the rate or yield of the reaction under mechanochemical conditions. We believe this is partly due to the gaseous nature of the water vapor in the air compared to the dissolved water and oxygen in solution.
Making kinetic and thermodynamic enolates via solvent-free high speed ball milling
Waddell, Daniel C.,Thiel, Indre,Clark, Tammara D.,Marcum, S. Tyler,MacK, James
supporting information; experimental part, p. 209 - 211 (2011/02/28)
We investigated the ability to selectively form products arising from a kinetic or a thermodynamic enolate under solvent-free high speed ball milling conditions. Using 2-methylcyclohexanone as the substrate and sodium hydroxide or lithium hexamethyldisila
