106428-11-9

Upstream product

• 106306-00-7 4(Z)-erythro-8-hydroxy-7-hydroxymethyl-8-o-methoxyphenyl-4-octenoic acid 
• 106305-99-1 (Z)-6-[(4R,5S)-4-(2-Methoxy-phenyl)-2,2-dimethyl-[1,3]dioxan-5-yl]-hex-4-enoic acid 

Downstream Products

• 106427-72-9 (4Z)-6-<(2RS,4RS,5SR)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl>hex-4-enoic acid 

Relevant academic research and scientific papers

Improved synthetic routes to the novel thromboxane receptor antagonist ICI 192605: Activity of synthetic 1.3-dioxane intermediates

A study of the synthetic routes to the thromboxane receptor antagonist ICI 192605 4(Z)-6-(2-o-chlorophenyl-4- o-hydroxyphenyl- 1,3-dioxan-cis-5-yl) hexenoic acid is described which led to an improvement in overall synthetic yield from 20 to 55%. In-vitro