106471-24-3

Basic information

• Product Name: (1R,2S,3S/1S,2R,3R)-2-methyl-3-phenyl-1-p-tolyl-1,3-propanediol
• CAS NO: 106471-24-3
• Molecular Weight: 256.345
• Mol File: 106471-24-3.mol

Chemical Properties

• CAS DataBase Reference: (1R,2S,3S/1S,2R,3R)-2-methyl-3-phenyl-1-p-tolyl-1,3-propanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,3S/1S,2R,3R)-2-methyl-3-phenyl-1-p-tolyl-1,3-propanediol(106471-24-3)
• EPA Substance Registry System: (1R,2S,3S/1S,2R,3R)-2-methyl-3-phenyl-1-p-tolyl-1,3-propanediol(106471-24-3)

Safety Data

• Hazardous Substances Data: 106471-24-3(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 207446-10-4 (Z)-dimethyl(1-phenylprop-1-enyloxy)silane 
• 63914-58-9 1-(4-methylphenyl)-2-methyl-3-phenylpropan-1,3-dione 

Relevant articles and documents

Tandem aldol-reduction reaction of dimethylsilyl enolates: A new method for stereoselective preparation of 1,3-diols

In the presence of a catalytic amount of TBAF (Bu4NF), dimethylsilyl enolates derived from acyclic ketones reacted with aldehydes to give syn,syn-1,3-diols 7a and 8a with moderate to high diastereoselectivity. The stereochemical outcome can be attributed to a syn-selective aldol reaction and the subsequent 1,2-syn-selective intramolecular reduction.

Chelation- and Nonchelation-Controlled Reductions of β-Dicarbonyl Compounds to 1,3-Diols with Three Chiral Centers

1,3-Diols 5 with three chiral centers are easily obtained, as a diastereoisomer mixture, by reduction of β-dicarbonyl compounds 4 with lithium aluminum hydrides.The diastereoisomer ratio depends largely on the solvent and the nature of the reducing agent.