106499-33-6

Basic information

• Product Name: (R)-1-(4-Isobutyl-phenyl)-1,1-dimethoxy-propan-2-ol
• Synonyms: (R)-1-(4-Isobutyl-phenyl)-1,1-dimethoxy-propan-2-ol
• CAS NO: 106499-33-6
• Molecular Weight: 252.354
• Mol File: 106499-33-6.mol

Chemical Properties

• CAS DataBase Reference: (R)-1-(4-Isobutyl-phenyl)-1,1-dimethoxy-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4-Isobutyl-phenyl)-1,1-dimethoxy-propan-2-ol(106499-33-6)
• EPA Substance Registry System: (R)-1-(4-Isobutyl-phenyl)-1,1-dimethoxy-propan-2-ol(106499-33-6)

Safety Data

• Hazardous Substances Data: 106499-33-6(Hazardous Substances Data)

Upstream product

• 124-41-4 sodium methylate 
• 85277-57-2 (S)-(-)-1-(4-isobutylphenyl)-2-methylsulfonyloxy-1-propanone 

Downstream Products

• 81576-55-8 (S)-(+)-methyl 2-(4-isobutylphenyl)propionate 
• 81576-57-0 (R)-ibuprofen methyl ester 

Relevant articles and documents

Preparation of Methyl 2-Arylpropanoates by the Reaction of 2-Hydroxypropiophenone Dimethyl Acetals with Sulfuryl Chloride in the Presence of an Amide or a Weak Base

Treatment of 2-hydroxypropiophenone dimethyl acetals (1; R=H, i-Bu, OMe, Ph, Br) with sulfuryl chloride in the presence of an amide or a weak base affords methyl 2-arylpropanoates (2) in good to excellent yields via 1,2-aryl migration of 1.The hydrolysis of 2 leads to the corresponding acids some of which are pharmaceutically important compounds having nonsteroidal anti-inflammatory and analgesic acivities.The aryl migration proceeds stereospecifically with complete inversion of configuration at the β-carbon atom.