106500-59-8Relevant academic research and scientific papers
Method for producing 1,2-benzisothiazol-3-ones
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, (2008/06/13)
A method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-(alkylthio)benzaldehyde with a hydroxylamine to give a 2-(alkylthio)benzaldehyde oxime and carrying out a reaction of the 2-(alkylthio)benzaldehyde oxime with a halogenating agent; and a method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-halobenzonitrile with an alkanethiol in a heterogeneous solvent system in the presence of a base to give a 2-(alkylthio)benzonitrile and carrying out a reaction of the 2-(alkylthio)benzonitrile with an halogenating agent in the presence of water.
Diethyl 3,6-Dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11-dicarboxylates as Calcium Entry Antagonists: New Conformationally Restrained Analogues of Hantzsch 1,4-Dihydropyridines Related to Nitrendipine as Probes for Receptor-Site Conformation
Baldwin, John J.,Claremon, David A.,Lumma, Patricia K.,McClure, David E.,Rosenthal, Seth A.,et al.
, p. 690 - 695 (2007/10/02)
The pharmacological activity of rigid analogues of 1,4-dihydropyridine calcium entry antagonists 9-16 is demonstrated by dose-dependent inhibition of the calcium concentration in depolarized rat aortic strips and by a nitrendipine binding assay in usi
