227466-50-4Relevant academic research and scientific papers
AMIDE-SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHα RESPONSES
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Paragraph 00286, (2014/05/24)
Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.
Diethyl 3,6-Dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11-dicarboxylates as Calcium Entry Antagonists: New Conformationally Restrained Analogues of Hantzsch 1,4-Dihydropyridines Related to Nitrendipine as Probes for Receptor-Site Conformation
Baldwin, John J.,Claremon, David A.,Lumma, Patricia K.,McClure, David E.,Rosenthal, Seth A.,et al.
, p. 690 - 695 (2007/10/02)
The pharmacological activity of rigid analogues of 1,4-dihydropyridine calcium entry antagonists 9-16 is demonstrated by dose-dependent inhibition of the calcium concentration in depolarized rat aortic strips and by a nitrendipine binding assay in usi
