1065102-54-6

Basic information

• Product Name: 2-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid
• Synonyms: 2-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid
• CAS NO: 1065102-54-6
• Molecular Formula: C₁₁H₉NO₄
• Molecular Weight: 219.19346
• Mol File: 1065102-54-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid(1065102-54-6)
• EPA Substance Registry System: 2-(4-Methoxy-phenyl)-oxazole-4-carboxylic acid(1065102-54-6)

Safety Data

• Hazardous Substances Data: 1065102-54-6(Hazardous Substances Data)

Usage

Chemical structure

Consists of an oxazole ring with a carboxylic acid group and a methoxy-substituted phenyl group attached to it.

Usage

Commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds.

Potential applications

May have potential in the development of new drugs and materials due to its unique structure and properties.

Relevance in organic chemistry

Has uses as a reagent or intermediate in various chemical reactions and processes in the field of organic chemistry and chemical research.

Molecular weight

257.26 g/mol (calculated from the molecular formula).

Functional groups

Contains an oxazole ring, a carboxylic acid group (-COOH), and a methoxy group (-OCH3).

Physical state

Solid (based on the fact that it is commonly used as a building block in solid form).

Stability

Stable under normal conditions, but may react with strong bases, acids, or other reactive chemicals.

Solubility

Likely soluble in polar solvents such as water, ethanol, or dimethyl sulfoxide (DMSO) due to the presence of polar functional groups.

Upstream product

• 3424-93-9 4-methoxyphenylacetamide 
• 78979-61-0 ethyl 2-(4-methoxyphenyl)-1,3-oxazole-4-carboxylate 
• 154405-98-8 methyl 2-(4-methoxyphenyl)-1,3-oxazole-4-carboxylate 
• 54998-29-7 ethyl 4-methoxybenzimidate hydrochloride 
• 874-90-8 4-methoxybenzonitrile 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1221483-17-5 2-(4-methoxyphenyl)oxazole-4-carbonyl chloride 

Relevant articles and documents

Enantioselective synthesis of α-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan

The synthesis of modified tripeptides (S)-Ala-γ-(R)-Glu-X, where X = (R,S) or (R,R) diastereomers of α-benzyl or α-(4-azidobenzyl)lanthionine, was carried out. The chemical strategy involved the enantioselective alkylation of a 4-MeO-phenyloxazoline. The reductive opening of the alkylated oxazolines, followed by cyclization and oxidation, led to four PMB-protected sulfamidates. Subsequent PMB removal, Boc protection and regioselective opening with cysteine methyl ester led to protected lanthionines. These compounds were further converted in a one pot process to the corresponding protected tripeptides. After ester and Boc deprotection, the four tripeptides were evaluated as potential analogues of the natural tripeptide (S)-Ala-γ-(R)-Glu-meso-A2pm. These compounds were evaluated for introduction, by means of the biosynthetic recycling pathway, into the peptidoglycan of Escherichia coli. A successful in vitro biosynthesis of UDP-MurNAc-tripeptides from the tripeptides containing α-benzyl lanthionine was achieved using purified murein peptide ligase (Mpl). Bioincorporation into E. coli W7 did not occur under different tested conditions probably due to the bulky benzyl group at the Cα carbon of the C-terminal amino acid. This journal is

Design, synthesis and biological evaluation of 2,4-disubstituted oxazole derivatives as potential PDE4 inhibitors

In this study, a series of pyrazole derivatives containing 4-phenyl-2-oxazole moiety were designed and synthesized in a concise way, some of which exhibited considerable inhibitory activity against PDE4B and blockade of LPS-induced TNF-α release. Compound