106522-00-3

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 22, p. 652, 1957 DOI: 10.1021/jo01357a017

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 98-86-2 acetophenone 
• 10486-61-0 3-thienyl iodide 
• 84553-32-2 α-Methylenebenzyl formate 

Relevant academic research and scientific papers

Electron transport and ultrafast spectroscopic studies of new methanofullerenes bearing a heteroatom in the exohedral chain

Fullerene derivatives (C60 and C70) have been widely used in excitonic solar cells due to their exceptional electron accepting properties and low reorganization energies. In recent years, a wide variety of fullerene-based n-Type materials have been developed, showing tremendous potential in the field of organic photovoltaics. However, only a few studies have been performed on heteroatom bearing methanofullerenes and their opto-electronic properties for use as n-Type organic semiconductor materials. In the present study, we report the synthesis of two mono-substituted methanofullerene derivatives, i.e., C60-Th (Product 1) and C60-TPA (Product 2), with a heteroatom (S and N, respectively) in the exohedral chain attached via an ethylene linker to the cyclopropane ring, and a comprehensive study of their photophysical and electrochemical properties. The methanofullerene derivatives have been synthesized using an amine-Assisted cycloaddition (AACA) reaction method. The structures of the synthesized products were established via different spectroscopic techniques. Reasonable quenching efficiencies were observed with respect to the fluorescence emission in mixtures with the donor polymer P3HT using both methanofullerenes. The electron transport properties were evaluated through fabricating electron-only devices, and 10 and 6 times higher mobilities were found compared to PC61BM for Products 1 and 2, respectively. Finally, the charge transfer properties were evaluated in mixtures with P3HT via transient absorption spectroscopy to study the ultrafast charge separation and formation of long-lived charge-separated states. The study suggests that both the products show excellent electron transport properties and the formation of longer-lived charge-separated states in mixtures with the donor polymer for use as n-Type materials for organic solar cells.

Unsaturated ketone compound as well as preparation method and application thereof

The present invention relates to a novel GPR52 antagonist. Specifically, the invention relates to an unsaturated ketone compound, a pharmaceutically acceptable salt, a stereoisomer or a prodrug molecule thereof, and a method for preparing a pharmaceutical composition thereof. The invention further relates to the use of the GPR52 antagonist as an orphan G protein coupled receptor GPR52 antagonist,and further relates to the use of the GPR52 antagonist in the preparation of drugs for preventing and treating Huntington's disease.

1-Arylvinyl formats: A New CO Source and Ketone Source in Carbonylative Synthesis of Chalcone Derivatives

1-Arylvinyl formates as a kind of new CO surrogate have been explored for the first time. Most of the known CO precursors usually produce undesired residuals, which have to be removed. In this strategy, after CO release, the in situ generated acetophenones from 1-arylvinyl formates can be successfully applied as a good ketone source in the synthesis of chalcones with benzaldehydes via a palladium-catalyzed reductive carbonylation reaction. A variety of chalcones were isolated in satisfactory to good yields with good substrates compatibilities under mild conditions.

Kinetic Resolution of β-Hydroxy Carbonyl Compounds via Enantioselective Dehydration Using a Cation-Binding Catalyst: Facile Access to Enantiopure Chiral Aldols

A practical and highly enantioselective nonenzymatic kinetic resolution of racemic β-hydroxy carbonyl (aldol) compounds through enantioselective dehydration process was developed using a cation-binding Song's oligoethylene glycol (oligoEG) catalyst with p