1065273-67-7Relevant academic research and scientific papers
Highly enantioselective synthesis of N,N-dialkvlbenzamides with aryl-carbonyl axial chirality by rhodium-catalyzed [2+2+2] cycloaddition
Suda, Takeshi,Noguchi, Keiichi,Hirano, Masao,Tanaka, Ken
, p. 6593 - 6596 (2008)
A study was conducted to demonstrate the enantioselective synthesis of axially chiral compounds by cationic rhodium(I)/modified-binapcatalyzed (2+2+2) cycloadditions. The study investigated a rhodium-catalyzed (2+2+2) cycloaddition of malonate-derived 1,6-diyne with N,N-diisopropylalkynylamide, bearing a sterically demanding 2-methoxypropyl group at an alkyne terminus, by employing various axially chiral biarylbisphosphine ligands. The scope of cycloaddition was also examined in terms of N,N-diisopropylalkynylamide. The generality of cycloaddition was examined in terms of 1,6-diyne. It was found that the methyl group at the ortho position of N,N-diisopropylalkynylamide is essential, to construct the stable axial chirality.
