106531-52-6

Basic information

• Product Name: Furo[2,3-c]pyridin-3(2H)-one (9CI)
• Synonyms: Furo[2,3-c]pyridin-3(2H)-one (9CI);Furo[2,3-c]pyridin-3(2H)-one;2H,3H-furo[2,3-c]pyridin-3-one;Furo[2,3-c]pyridin-3-one
• CAS NO: 106531-52-6
• Molecular Formula: C7H5NO2
• Molecular Weight: 135.1201
• Product Categories: PYRIDINE
• Mol File: 106531-52-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 290℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.360
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Furo[2,3-c]pyridin-3(2H)-one (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[2,3-c]pyridin-3(2H)-one (9CI)(106531-52-6)
• EPA Substance Registry System: Furo[2,3-c]pyridin-3(2H)-one (9CI)(106531-52-6)

Safety Data

• Hazardous Substances Data: 106531-52-6(Hazardous Substances Data)

Usage

General Description

Furo[2,3-c]pyridin-3(2H)-one (9CI) is a chemical compound with the molecular formula C6H5NO. It is a heterocyclic organic compound and is classified as a pyridine derivative. Furo[2,3-c]pyridin-3(2H)-one (9CI) is a white solid with a melting point of 231-232°C. It is used in pharmaceutical research and drug discovery as a potential scaffold for the development of new therapeutic compounds. This chemical has potential applications in the field of medicinal chemistry, particularly in the development of drugs targeting specific biological pathways and mechanisms. Additionally, it is also used as a building block in organic synthesis for the creation of various functional molecules.

Upstream product

• 106531-50-4 Ethyl 3-Hydroxyfuro<2,3-c>pyridine-2-carboxylate 
• 119292-95-4 3-ethoxyfuro<2,3-c>pyridine 

Relevant articles and documents

HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Furopyridines. IX . Syntheses and Properties of 3-Ethoxy Derivatives of Furo-, Furo-, Furo- and Furopyridine

Reaction of ethyl 3-ethoxycarbonylmethoxyfuropyridine-2-carboxylates 2a-2d with sodium ethoxide afforded 3-ethoxy derivatives 3a-3d which converted to 3-ethoxyfuropyridines 5a-5d by hydrolysis and decarboxylation of the ester group.Vilsmeier reaction of 5a and 5b gave 2-formyl-3-ethoxy derivatives 6a and 6b and 2-formyl-3-chloro derivatives 7a and 7b, while 5c and 5d did not give any formyl compound.Bromination of 3-ethoxyfuropyridines with 1 equivalent mole of bromine gave 2-bromo-3-ethoxyfuropyridines 9a-9d, whereas reaction with 3 equivalents of bromine yielded 2,2- dibromo-3,3-diethoxy-2,3-dihydrofuropyridines (10a and 10b) and/or 2-bromo-3,3-diethoxy-2,3-dihydrofuropyridines 11b, 11c and 11d.Treatment of compounds 5a-5d with n-butyllithium in hexane-tetrahydrofuran at -70 deg C and subsequent addition of N,N-dimethylformamide yielded 2-formyl derivatives 6a-6d.