106531-52-6

Usage

Uses

Used in Pharmaceutical Research and Drug Discovery:
Furo[2,3-c]pyridin-3(2H)-one (9CI) is used as a potential scaffold for the development of new therapeutic compounds. Its unique structure and properties allow it to target specific biological pathways and mechanisms, making it a promising candidate for the creation of drugs with novel therapeutic effects.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Furo[2,3-c]pyridin-3(2H)-one (9CI) is employed as a building block for the synthesis of various functional molecules. Its versatility and reactivity enable the development of compounds with specific biological activities, contributing to the advancement of drug discovery and the treatment of various diseases.
Used in Organic Synthesis:
Furo[2,3-c]pyridin-3(2H)-one (9CI) is also used as a key intermediate in organic synthesis. Its ability to form diverse chemical structures makes it an essential component in the creation of a wide range of functional molecules, further expanding its applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 106531-50-4 Ethyl 3-Hydroxyfuro<2,3-c>pyridine-2-carboxylate 
• 119292-95-4 3-ethoxyfuro<2,3-c>pyridine 

Relevant academic research and scientific papers

HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Furopyridines. IX . Syntheses and Properties of 3-Ethoxy Derivatives of Furo-, Furo-, Furo- and Furopyridine

Reaction of ethyl 3-ethoxycarbonylmethoxyfuropyridine-2-carboxylates 2a-2d with sodium ethoxide afforded 3-ethoxy derivatives 3a-3d which converted to 3-ethoxyfuropyridines 5a-5d by hydrolysis and decarboxylation of the ester group.Vilsmeier reaction of 5a and 5b gave 2-formyl-3-ethoxy derivatives 6a and 6b and 2-formyl-3-chloro derivatives 7a and 7b, while 5c and 5d did not give any formyl compound.Bromination of 3-ethoxyfuropyridines with 1 equivalent mole of bromine gave 2-bromo-3-ethoxyfuropyridines 9a-9d, whereas reaction with 3 equivalents of bromine yielded 2,2- dibromo-3,3-diethoxy-2,3-dihydrofuropyridines (10a and 10b) and/or 2-bromo-3,3-diethoxy-2,3-dihydrofuropyridines 11b, 11c and 11d.Treatment of compounds 5a-5d with n-butyllithium in hexane-tetrahydrofuran at -70 deg C and subsequent addition of N,N-dimethylformamide yielded 2-formyl derivatives 6a-6d.