106531-50-4Relevant academic research and scientific papers
HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
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Page/Page column, (2014/06/24)
The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES
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, (2013/09/12)
The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES
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, (2013/09/12)
Disclosed are certain pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds and methods of treatment using such compounds.
AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES
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, (2013/09/12)
Disclosed are certain amido-benzyl sulfone and sulfonamide compounds, pharmaceutical compositions comprising such compounds, land methods of treatment using such compounds.
ALKYL-AND DI-SUBSTITUTED AMIDO-BENZYL SULFONAMIDE DERIVATIVES
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, (2013/09/12)
The present invention relates to certain alkyl- and di-substituted amido-benzyl sulfonamide compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment of NAMPT-mediated disorders, such as diabetes, rheumatoid arthritis,
AMIDO SPIROCYCLIC AMIDE AND SULFONAMIDE DERIVATIVES
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Page/Page column 142, (2013/09/12)
Provided are amido spirocyclic amide and sulfonamide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
AMIDO-BENZYL SULFOXIDE DERIVATIVES
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Paragraph 0168, (2013/09/12)
The present invention relates to certain amido-benzyl sulfoxide compounds, pharmaceutical compositions comprising such compounds, and methods of treatment of an NAMPT-mediated disease or condition in a subject, selected from solid or liquid tumor, rheumat
HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
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Page/Page column 69, (2013/03/26)
The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, Y and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.
The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors
Buckmelter, Alex J.,Ren, Li,Laird, Ellen R.,Rast, Bryson,Miknis, Greg,Wenglowsky, Steve,Schlachter, Stephen,Welch, Mike,Tarlton, Eugene,Grina, Jonas,Lyssikatos, Joseph,Brandhuber, Barbara J.,Morales, Tony,Randolph, Nikole,Vigers, Guy,Martinson, Matthew,Callejo, Michele
, p. 1248 - 1252 (2011/04/16)
Virtual and high-throughput screening identified imidazo[1,2-a]pyrazines as inhibitors of B-Raf. We describe the rationale, SAR, and evolution of the initial hits to a series of furo[2,3-c]pyridine indanone oximes as highly potent and selective inhibitors
RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF
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Page/Page column 19, (2010/04/23)
Compounds of Formulas (I), (IIA) and (IIIA) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formulas (I), (IIA) and (IIIA) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
