106535-70-0

Upstream product

• 106549-11-5 2-Bromo-1-(2,2,8,8-tetramethyl-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromen-6-yl)-ethanone 
• 78968-62-4 6-acetyl-2,2,8,8-tetramethyl-3,4,9,10-tetrahydro-2H,8H-benzo<1,2-b:3,4-b'>dipyran 
• 98-88-4 benzoyl chloride 
• 106535-64-2 4-(2,2,8,8-Tetramethyl-3,4,9,10-tetrahydro-2H,8H-pyrano[2,3-f]chromen-6-yl)-thiazol-2-ylamine 

Relevant academic research and scientific papers

Synthesis of Some 2-Amino- and 2-Mercapto-4-chromanylthiazoles and Their Derivatives as Antifungal and Antibacterial Agents

Bromination of 6-acetylchromans (1, 9, 17) gives a mixture of monobromo (major) and dibromo (minor) acetyl derivatives.The monobromoacetyl derivatives (1b, 9b, 17b) on condensation with thiourea afford 2-amino-4-chromanylthiazoles (2, 10, 18).These 2-aminothiazoles are also obtained when the corresponding 6-acetylchromans (1, 9, 17) are condensed with thiourea in the presence of iodine.Acetylation and benzoylation of 2-aminothiazoles afford the corresponding acetyl (3, 11, 19) and benzoyl (4, 12, 20) derivatives.Condensation of monobromoacetylchromans (1b, 9b, 17b) with ammonium dithiocarbamate affords the corresponding 2-mercaptothiazoles (5, 13, 21). 8-Methyl, 8-ethyl and S-carbomethoxymethyl derivatives of 2-mercaptothiazoles have also been prepared.All the thiazoles synthesised (2-8, 10-16, 18-24) have been tested for their antifungal and antibacterial activities.