106536-38-3

Basic information

• Product Name: 6'-amino-3'-methyl-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile
• Synonyms: 6'-amino-3'-methyl-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile;6-amino-3-methyl-2'-oxo-1,1',3',4-tetrahydrospiro(pyrano[2,3-c]pyrazole-4,3'-[2'H]-indole)-5-carbonitrile
• CAS NO: 106536-38-3
• Molecular Formula: C15H11N5O2
• Molecular Weight: 293.28014
• Mol File: 106536-38-3.mol
• Article Data: 41

Chemical Properties

• Melting Point: 275 °C(Solv: acetone (67-64-1))
• Boiling Point: 718.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.59±0.1 g/cm3(Predicted)
• PKA: 10.11±0.60(Predicted)
• CAS DataBase Reference: 6'-amino-3'-methyl-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6'-amino-3'-methyl-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile(106536-38-3)
• EPA Substance Registry System: 6'-amino-3'-methyl-2-oxo-1,2-dihydro-1'H-spiro[indole-3,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile(106536-38-3)

Safety Data

• Hazardous Substances Data: 106536-38-3(Hazardous Substances Data)

Upstream product

• 6623-89-8 2-oxo-2,3-dihydroindolylidenemalononitrile 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 91-56-5 indole-2,3-dione 
• 141-97-9 ethyl acetoacetate 
• 109-77-3 malononitrile 
• 105-45-3 acetoacetic acid methyl ester 
• 937063-51-9 3-methyl-1,5-dihydro-4H-pyrazol-4-one 
• 674-82-8 4-methyleneoxetan-2-one 
• 132712-71-1 5-hydroxy-3-methylpyrazole 
• 302-01-2 hydrazine 

Relevant articles and documents

Novel Synthesis of Furoindole Derivatives

Isatin reacted with diethyl 3-amino-2-cyano-2-pentenedioate in ethanol and in presence of Et3N to give 3-(1-amino-2-cyano-2-ethoxycarbonyl)ethenyl-2H-furoindol-2-one.The reaction of (2-oxo-3-indolinylidene)-malononitrile (3a) with the diethyl ester

Ultrasound Promoted Green Synthesis of Spiro Indoline-3,4′-pyrano[2,3-c]pyrazoles

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Preparation and characterization of a novel organic–inorganic hybrid nanostructure: application in synthesis of spirocompounds

Abstract: Immobilization and heterogenization of acidic/basic groups or organic tags on inorganic supports have found many important applications in recent years. In this investigation, a new hybrid organic–inorganic nanostructure was prepared. The struct

Iodine-Catalyzed One-Pot Four-Component Synthesis of Spiro[indoline-3,4′-pyrano-pyrazole] Derivatives

An efficient, facile, and useful synthetic method was developed for the production of spiro[indoline-3,4′-pyrano-pyrazole] carbonitrile derivatives through a one-pot, four-component reaction involving hydrazine hydrate, diketene, substituted isatins, and malononitrile or ethyl cyanoacetate in the presence of iodine as the efficient catalyst in ethanol at room temperature. Significantly, this remarkable method provides novel spiropyranopyrazole derivatives in good to high yields. The significant aspects of this protocol are facile work-up approach and a greener process because the use of toxic and hazardous solvents are avoided.

Green Synthesis of Pyrano[2,3-c]pyrazoles and Spiro[indoline-3,4′-pyrano[2,3-c]pyrazoles] Using Nano-silica Supported 1,4-Diazabicyclo[2.2.2]octane as a Novel Catalyst

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Ce(III) immobilized on aminated poly(vinyl chloride): high-performance synergistic bifunctional acid–base catalyst for one-pot synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles

A bifunctional acid–base catalyst of CeIII immobilized on ethylenediamine (EDA)-grafted poly(vinyl chloride) (PVC) has been prepared by a simple approach. First, PVC was treated with EDA to afford aminated poly(vinyl chloride) (PVC–EDA). Therea

Non-catalytic thermal multicomponent assembling of isatin, cyclic CH-acids and malononitrile: An efficient approach to spirooxindole scaffold

Thermal non-catalytic reaction of isatin, cyclic CH-acids and malononitrile in water or alcohols affords substituted spirooxindoles in 90-97% yields.

Meglumine promoted one-pot, four-component synthesis of pyranopyrazole derivatives

Meglumine, a bio-based chemical, was demonstrated to be a highly efficient and reusable catalyst for the synthesis of a series of pyranopyrazole derivatives via a one-pot, four-component reaction of carbonyl compound or isatin, hydrazine hydrate, malononi

N-Sulfonic acid modified poly(styrene-co-maleic anhydride): An efficient and recyclable solid acid catalyst for the synthesis of a wide range of spiropyrans

N-Sulfonic acid modified poly(styrene-co-maleic anhydride) as a recyclable solid acid catalyst efficiently catalyzed the one-pot three-component synthesis of spiropyran derivatives through a simple, convenient, and cost-effective approach in good yields a

Alpha-Casein: an efficient, green, novel, and eco-friendly catalyst for one-pot multi-component synthesis of bis (pyrazol-5-ols), dihydro-pyrano[2,3-c]pyrazoles and spiropyranopyrazoles in an environmentally benign manner

For the first time, alpha-Casein was used as an efficient and eco-friendly catalyst for an effective and facile preparation of dihydropyranopyrazoles and spiropyranopyrazoles. The synthesis of bis (pyrazol-5-ols) derivatives was developed via one-pot, pseudo-five-component condensation, and the target dihydropyrano[2,3-c]pyrazoles and spiropyranopyrazoles were prepared by one-pot four-component reaction. This new method of employing alpha-Casein, which is a green, recyclable, non-toxic and commercially available catalyst, offers advantages such as mild condition, short reaction times, easy work-up, no need for column chromatography, and high yields of the products which make it more economic than other environmentally synthetic protocols.

Supported palladium oxide nanoparticles in Al-SBA-15 as an efficient and reusable catalyst for the synthesis of pyranopyrazole and benzylpyrazolyl coumarin derivatives via multicomponent reactions

An eco-friendly method for diversity-oriented synthesis of substituted dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been achieved via one-pot and multicomponent reaction in the presence of PdO/Al-SBA-15 as an efficient and rec

Preparation of GO/SiO2/PEA as a new solid base catalyst for the green synthesis of some spirooxindole derivatives

Efficient and green one pot multi component synthesis of some spirooxindole derivatives in the presence of graphene oxide functionalized with 2-(1-piperazinyl) ethylamine (GO/SiO2/PEA) as a solid base catalyst was studied. GO/SiO2/PEA has been obtained through a two step reaction and characterized by Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), thermo gravimetric analysis (TGA), Raman spectroscopy and X-ray diffraction (XRD). Green reaction conditions, short reaction times, reusable catalyst and a high to excellent yield of products are some of the advantageous of the presented method.