106536-38-3

Upstream product

• 6623-89-8 2-oxo-2,3-dihydroindolylidenemalononitrile 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 91-56-5 indole-2,3-dione 
• 109-77-3 malononitrile 
• 141-97-9 ethyl acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 
• 132712-71-1 5-hydroxy-3-methylpyrazole 
• 937063-51-9 3-methyl-1,5-dihydro-4H-pyrazol-4-one 
• 674-82-8 4-methyleneoxetan-2-one 
• 302-01-2 hydrazine 

Relevant academic research and scientific papers

Novel Synthesis of Furoindole Derivatives

Isatin reacted with diethyl 3-amino-2-cyano-2-pentenedioate in ethanol and in presence of Et3N to give 3-(1-amino-2-cyano-2-ethoxycarbonyl)ethenyl-2H-furoindol-2-one.The reaction of (2-oxo-3-indolinylidene)-malononitrile (3a) with the diethyl ester

A convenient route toward one-pot multicomponent synthesis of spirochromenes and pyranopyrazoles accelerated via quinolinic acid

In the present work, the catalytic activity of quinolinic acid (QUIN) was studied for the synthesis of spirochromene and pyranopyrazole derivatives from readily available materials. The salient features of these one-pot multicomponent protocols are the clean reaction profile, easy isolation of products, no chromatographic separation techniques, high efficiency, short reaction time, and high yield of products plus using QUIN as a new, inexpensive, commercially available, and efficient organocatalyst.

[bmim]OH: An efficient catalyst for the synthesis of mono and bis spirooxindole derivatives in ethanol at room temperature

A rapid and efficient, one pot synthesis of spirooxindole derivatives has been attempted by three-component reaction of isatin, malononitrile and carbonyl compound possessing a reactive α-methylene group by using task specific ionic liquid, 1-butyl-3-meth

Preparation and characterization of a novel organic–inorganic hybrid nanostructure: application in synthesis of spirocompounds

Abstract: Immobilization and heterogenization of acidic/basic groups or organic tags on inorganic supports have found many important applications in recent years. In this investigation, a new hybrid organic–inorganic nanostructure was prepared. The struct

Carbon-SO3H: A novel and recyclable solid acid catalyst for the synthesis of spiro[4H-pyran-3,3′-oxindoles]

A bioglycerol derived carbon-sulfonic acid is found to catalyze efficiently the three-component one-pot condensation of isatin, malononitrile, and 1,3-dicarbonyls to afford a wide range of spiro[4H-pyran-3,3′-oxindole] derivatives in good yields and selec

Iodine-Catalyzed One-Pot Four-Component Synthesis of Spiro[indoline-3,4′-pyrano-pyrazole] Derivatives

An efficient, facile, and useful synthetic method was developed for the production of spiro[indoline-3,4′-pyrano-pyrazole] carbonitrile derivatives through a one-pot, four-component reaction involving hydrazine hydrate, diketene, substituted isatins, and malononitrile or ethyl cyanoacetate in the presence of iodine as the efficient catalyst in ethanol at room temperature. Significantly, this remarkable method provides novel spiropyranopyrazole derivatives in good to high yields. The significant aspects of this protocol are facile work-up approach and a greener process because the use of toxic and hazardous solvents are avoided.

Cu (II)-β-cyclodextrin complex stabilized on magnetic nanoparticles: A retrievable hybrid promoter for green synthesis of spiropyrans

The magnetic core of manganese ferrite (MnFe2O4) nanoparticles has a significant stability in comparison with ferrite (Fe3O4) nanoparticles. The unique supramolecular properties of β-cyclodextrin (β-CD), such as

Synthesis of spirochromene derivatives catalyzed by Mn(bpyo)2/MCM-41 in water

A three-component one-pot synthesis of spirochromene derivatives by condensing cyclic 1,3-diketones, isatin or acenaphthenequinone, and malononitrile using a catalytic amount of Mn(bpyo)2/MCM-41 in refluxing water is reported.

Ce(III) immobilized on aminated poly(vinyl chloride): high-performance synergistic bifunctional acid–base catalyst for one-pot synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles

A bifunctional acid–base catalyst of CeIII immobilized on ethylenediamine (EDA)-grafted poly(vinyl chloride) (PVC) has been prepared by a simple approach. First, PVC was treated with EDA to afford aminated poly(vinyl chloride) (PVC–EDA). Therea

Synthesis of a novel DABCO-based nanomagnetic catalyst with sulfonic acid tags: application to the synthesis of diverse spiropyrans

Abstract: In this paper, sulfonic acid functionalized 1,4-diazabicyclo[2.2.2]octane (DABCO)-based magnetic nanoparticle Fe3O4 [Fe3O4@SiO2@Pr-DABCO-SO3H]Cl2 was synthesized and fu