106537-98-8

Upstream product

• 58663-02-8 5-phenyl-7-methylpyrazolo<4,3-c><1,2,5>oxadiazin-3(5H)-one 
• 105-53-3 diethyl malonate 
• 106538-00-5 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile 
• 64-17-5 ethanol 
• 52943-85-8 5-amino-3-methyl-4-nitroso-1-phenylpyrazole 

Relevant academic research and scientific papers

Anticancer and anti-inflammatory activities of some new pyrazolo[3,4-b]pyrazines

New derivatives of pyrazolo[3,4-b]pyrazines and related heterocycles were synthesized using 5-Amino-3-methyl-4-nitroso-1-phenyl-pyrazole (1) as a starting material. The 5-Acetyl derivative 15 was shown to be a useful key intermediate for the synthesis of several derivatives of pyrazolopyrazines. Some of the prepared compounds were evaluated for their anti-inflammatory and anti-breast cancer MCF-7 cell line activities. SAR study showed that compounds 15 and 29 exhibited remarkable anti-inflammatory activity, where 15 showed the same activity as that of the reference drug indomethacin. On the other hand, compounds 25i, 25j showed very significant inhibitory activity (p 0.001) against MCF-7 breast cancer cell line.