106539-41-7

Upstream product

• 136918-14-4 phthalimide 
• 4143-60-6 Diethyl azodicarboxylate 
• 77564-44-4 (R)-(+)-1,3-butanediol 1-benzyl ether 
• 4799-69-3 (S)-(-)-1,3-butanediol 1-benzyl ether 
• 100-44-7 benzyl chloride 
• 106539-39-3 [(1R)-3-benzyloxy-1-methylpropyl] acetate 
• 84184-35-0 Toluene-4-sulfonic acid 3-benzyloxy-1-methyl-propyl ester 
• 106539-38-2 (3S)-1-benzyloxy-3-(1-ethoxyethoxy)butane 

Relevant academic research and scientific papers

Stereospecific Synthesis of (2R,5R)-Hept-6-yne-2,5-diamine: A Potent and Selective Enzyme-activated Irreversible Inhibitor of Ornithine Decarboxylase (ODC)

Hept-6-yne-2,5-diamine (2) and 2-methylhept-6-yne-2,5-diamine (3), while structurally related to the potent ornithine decarboxylase (ODC) inhibitor hex-5-yne-1,4-diamine (1), are stable to in vivo oxidation by monoamine oxidase (MAO).Although the methyl substitution is at a carbon relatively remote from the site of metabolic attack by ornithine decarboxylase (ODC), it has a critical influence on the potencies of these compounds as inhibitors of the enzyme.Of the four stereoisomers, (2R,5R)-(2) is the most active.Unambiguous syntheses of each isomer of (2) from the dianion of 3-trimethylsilyl-N-butoxycarbonylprop-2-ynylamine (5) are presented.