1065488-37-0Relevant academic research and scientific papers
A metal-free tandem dehydrogenative α-arylation reaction of propargylic alcohols with 2-alkynylbenzaldoximes toward the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenone skeletons
Alatat, Khalil,Abbasi Kejani, Alireza,Nikbakht, Ali,Bijanzadeh, Hamid Reza,Balalaie, Saeed
, p. 579 - 583 (2022/02/01)
A tandem reaction of 2-alkynylbenzaldoximes with propargylic alcohols has been developed for the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenones. Employing 2-alkynylbenzaldoximes as a precursor in the presence of Br2 generates 4-bromo-isoquinoline-N-
Facile assembly of 1-(4-haloisoquinolin-1-yl)ureas via a reaction of 2-alkynylbenzaldoxime, carbodiimide, and halide in water
Lai, Lifang,Wang, Huanhuan,Wu, Jie
supporting information, p. 2246 - 2250 (2014/03/21)
1-(4-Haloisoquinolin-1-yl)ureas are generated efficiently via a tandem reaction of 2-alkynylbenzaldoxime, carbodiimide, with halide in water. The process involves the generation of halonium ion in situ by employment of NaI/oxone or NaBr/oxone as the promoters. This green process proceeds smoothly and efficiently, accommodating a variety of substituents to generate the desired products.
Generation of diverse isoquinoline N-oxides in an aqueous system
Wang, Huanhuan,Zhu, Mengdan,Ye, Shengqing,Wu, Jie
, p. 13626 - 13629 (2013/08/23)
4-Halo isoquinoline N-oxides could be synthesized efficiently via the electrophilic cyclization of 2-alkynylbenzaldoximes, involving the in situ generation of the halonium ion in water. The one-pot cyclization-Suzuki reaction in an aqueous system afforded
Three-component reactions of 2-alkynylbenzaldoximes and α,β-unsaturated carbonyl compounds with bromine or iodine monochloride
Ye, Shengqing,Gao, Ke,Wu, Jie
supporting information; experimental part, p. 1746 - 1751 (2010/09/07)
The three-component reaction of 2-alky-nylbenzaldoximes and α,β-unsaturated carbonyl compounds with bromine or iodine monochloride is described, which generates the unexpected 2-(4-halo-isoquinolin- 1-yl)ethanol derivatives in good to excellent yields
Multicatalytic tandem reactions of 2-alkynylbenzaldoximes with isocyanides
Chen, Zhiyuan,Yu, Xingxin,Su, Mingchao,Yang, Xiaodi,Wu, Jie
supporting information; experimental part, p. 2702 - 2708 (2009/12/31)
An efficient tandem reaction of 2-alkynylbenzaldoximes with isocyanides co-catalyzed by silver triflate and bismuth triflate has been developed, which gives rise to the unexpected JV-(isoquinolin-l-yl)formamides in good to excellent yields. The iodo- and
Iodine-mediated electrophilic cyclization of 2-alkynylbenzaldoximes leading to the formation of iodoisoquinoline N-oxides
Huo, Zhibao,Tomeba, Hisamitsu,Yamamoto, Yoshinori
, p. 5531 - 5533 (2008/12/22)
Reaction of 2-alkynylbenzaldoximes 1 with 5 equiv of iodine in EtOH at room temperature gives the corresponding iodoisoquinoline N-oxides 2 in good to excellent yields. The cyclization proceeds very smoothly and quickly without any additives such as bases
Access to functionalized isoquinoline N-oxides via sequential electrophilic cyclization/cross-coupling reactions
Ding, Qiuping,Wu, Jie
experimental part, p. 1850 - 1854 (2009/07/24)
Electrophilic cyclization of 2-alkynylbenzaldoximes with various electrophiles leads to the formation of 4-iodoisoquinoline N-oxides or 4-bromo-isoquinoline N-oxides under mild conditions. The reaction can be transferred to highly functionalized isoquinol
