1065488-39-2Relevant academic research and scientific papers
Facile assembly of 1-(4-haloisoquinolin-1-yl)ureas via a reaction of 2-alkynylbenzaldoxime, carbodiimide, and halide in water
Lai, Lifang,Wang, Huanhuan,Wu, Jie
supporting information, p. 2246 - 2250 (2014/03/21)
1-(4-Haloisoquinolin-1-yl)ureas are generated efficiently via a tandem reaction of 2-alkynylbenzaldoxime, carbodiimide, with halide in water. The process involves the generation of halonium ion in situ by employment of NaI/oxone or NaBr/oxone as the promoters. This green process proceeds smoothly and efficiently, accommodating a variety of substituents to generate the desired products.
Generation of diverse isoquinoline N-oxides in an aqueous system
Wang, Huanhuan,Zhu, Mengdan,Ye, Shengqing,Wu, Jie
, p. 13626 - 13629 (2013/08/23)
4-Halo isoquinoline N-oxides could be synthesized efficiently via the electrophilic cyclization of 2-alkynylbenzaldoximes, involving the in situ generation of the halonium ion in water. The one-pot cyclization-Suzuki reaction in an aqueous system afforded
Three-component reactions of 2-alkynylbenzaldoximes and α,β-unsaturated carbonyl compounds with bromine or iodine monochloride
Ye, Shengqing,Gao, Ke,Wu, Jie
supporting information; experimental part, p. 1746 - 1751 (2010/09/07)
The three-component reaction of 2-alky-nylbenzaldoximes and α,β-unsaturated carbonyl compounds with bromine or iodine monochloride is described, which generates the unexpected 2-(4-halo-isoquinolin- 1-yl)ethanol derivatives in good to excellent yields
Access to functionalized isoquinoline N-oxides via sequential electrophilic cyclization/cross-coupling reactions
Ding, Qiuping,Wu, Jie
supporting information; experimental part, p. 1850 - 1854 (2009/07/24)
Electrophilic cyclization of 2-alkynylbenzaldoximes with various electrophiles leads to the formation of 4-iodoisoquinoline N-oxides or 4-bromo-isoquinoline N-oxides under mild conditions. The reaction can be transferred to highly functionalized isoquinol
Iodine-mediated electrophilic cyclization of 2-alkynylbenzaldoximes leading to the formation of iodoisoquinoline N-oxides
Huo, Zhibao,Tomeba, Hisamitsu,Yamamoto, Yoshinori
, p. 5531 - 5533 (2008/12/22)
Reaction of 2-alkynylbenzaldoximes 1 with 5 equiv of iodine in EtOH at room temperature gives the corresponding iodoisoquinoline N-oxides 2 in good to excellent yields. The cyclization proceeds very smoothly and quickly without any additives such as bases
