1065509-98-9Relevant academic research and scientific papers
Stereochemical Control of Enzymatic Carbon–Carbon Bond-Forming Michael-Type Additions by “Substrate Engineering”
Miao, Yufeng,Tepper, Pieter G.,Geertsema, Edzard M.,Poelarends, Gerrit J.
supporting information, p. 5350 - 5354 (2016/11/22)
The enzyme 4-oxalocrotonate tautomerase (4-OT) promiscuously catalyzes the Michael-type addition of acetaldehyde to β-nitrostyrene derivatives to yield chiral γ-nitroaldehydes, which are important precursors for pharmaceutically active γ-aminobutyric acid
Remote sulfonamido group enhances reactivity and selectivity for asymmetric michael addition of nitroalkanes to α,β-unsaturated aldehydes
Huang, Yu-Chao,Uang, Biing-Jiun
supporting information, p. 2444 - 2448 (2014/11/07)
The pyrrolidine-camphorsulfonamide-based catalyst 1 a catalyzes the enantioselective conjugate addition of nitroalkanes to α,β- unsaturated aldehydes in the presence of five equivalents of water in iPrOH to give the corresponding chiral Michael adducts in good yields and high enantioselectivities (up to 99 % ee) with a catalyst loading as low as 1 mol%.
Highly enantioselective organocatalytic conjugate addition of nitromethane to α,β-unsaturated aldehydes: Three-step synthesis of optically active baclofen
Zu, Liansuo,Xie, Hexin,Li, Hao,Wang, Jian,Wang, Wei
, p. 2660 - 2664 (2008/09/19)
An efficient, organocatalytic, highly enantioselective, conjugate addition reaction of nitromethane with α,β-unsaturated aldehydes has been developed. The process serves as the key step for a practical 3-step synthesis of chiral baclofen, an antispastic drug.
