1418032-37-7

Basic information

• Product Name: (S)-3-(3-methoxyphenyl)-4-nitrobutan-1-ol
• Synonyms: (S)-3-(3-methoxyphenyl)-4-nitrobutan-1-ol
• CAS NO: 1418032-37-7
• Molecular Weight: 225.244
• Mol File: 1418032-37-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-3-(3-methoxyphenyl)-4-nitrobutan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(3-methoxyphenyl)-4-nitrobutan-1-ol(1418032-37-7)
• EPA Substance Registry System: (S)-3-(3-methoxyphenyl)-4-nitrobutan-1-ol(1418032-37-7)

Safety Data

• Hazardous Substances Data: 1418032-37-7(Hazardous Substances Data)

Upstream product

• 3179-09-7 (E)-1-methoxy-3-(2-nitrovinyl)benzene 
• 1065509-98-9 3-(3-methoxyphenyl)-4-nitrobutyraldehyde 
• 56578-36-0 3-methoxycinnamaldehyde 
• 3179-09-7 1-methoxy-3-(2-nitrovinyl)benzene 
• 75-07-0 acetaldehyde 

Relevant articles and documents

Stereochemical Control of Enzymatic Carbon–Carbon Bond-Forming Michael-Type Additions by “Substrate Engineering”

The enzyme 4-oxalocrotonate tautomerase (4-OT) promiscuously catalyzes the Michael-type addition of acetaldehyde to β-nitrostyrene derivatives to yield chiral γ-nitroaldehydes, which are important precursors for pharmaceutically active γ-aminobutyric acid

Asymmetric michael reaction of acetaldehyde with nitroolefins catalyzed by highly water-compatible organocatalysts in aqueous media

A novel category of diarylprolinol silyl ether catalysts which contain different lengths of alkylamine tags, was designed and synthesized. These catalysts were used, along with benzoic acid as the co-catalyst, to catalyze the asymmetric Michael reaction of the highly reactive acetaldehyde with nitroolefins. For the reactions studied, this catalytic system exhibited high reactivity in brine without any organic solvents; good yields (30-61%) and high enantioselectivities (80-97% ee) for a wide variety of nitrostyrenes were obtained.