106551-35-3

Basic information

• Product Name: 2-acetyl-4-methylphenyl 2-Chlorobenzoate
• Synonyms: 2-acetyl-4-methylphenyl 2-Chlorobenzoate
• CAS NO: 106551-35-3
• Molecular Weight: 288.73
• Mol File: 106551-35-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-acetyl-4-methylphenyl 2-Chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-acetyl-4-methylphenyl 2-Chlorobenzoate(106551-35-3)
• EPA Substance Registry System: 2-acetyl-4-methylphenyl 2-Chlorobenzoate(106551-35-3)

Safety Data

• Hazardous Substances Data: 106551-35-3(Hazardous Substances Data)

Upstream product

• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 118-91-2 ortho-chlorobenzoic acid 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 106551-40-0 1-(2-hydroxy-5-methylphenyl)-3-(2-chlorophenyl)propane-1,3-dione 
• 106551-53-5 2-(2'-chlorophenyl)-6-methyl-3-bromoflavone 

Relevant articles and documents

A New Protocol for Total Synthesis of Natural Product Frutinone A and Its Derivatives

A new protocol for total synthesis of natural product frutinone A was accomplished in three steps by using inexpensive 2′-hydroxyacetophenone as starting material. The key intermediate 3-(2-chlorobenzoyl)-4-hydroxycoumarin was synthesized in one pot through Baker-Venkataraman rearrangement of 2-acetylphenyl 2-chlorobenzoate followed by introduction of methyl chloroformate under basic conditions. Then, base-promoted intramolecular nucleophilic substitution reaction of 3-(2-chlorobenzoyl)-4-hydroxycoumarin provided frutinone A in excellent yield. The synthetic route features good yield, transition metal-free and mild reaction conditions, and high tolerance for functionality, thereby allowing easy substitutions around the frutinone A core.

Synthesis of some 2-(2'-chlorobenzoyl)coumaran-3-ones

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