106565-28-0Relevant academic research and scientific papers
Tandem aldol-reduction reaction of dimethylsilyl enolates: A new method for stereoselective preparation of 1,3-diols
Miura, Katsukiyo,Nakagawa, Takahiro,Suda, Shuntaro,Hosomi, Akira
, p. 150 - 151 (2007/10/03)
In the presence of a catalytic amount of TBAF (Bu4NF), dimethylsilyl enolates derived from acyclic ketones reacted with aldehydes to give syn,syn-1,3-diols 7a and 8a with moderate to high diastereoselectivity. The stereochemical outcome can be attributed to a syn-selective aldol reaction and the subsequent 1,2-syn-selective intramolecular reduction.
Chelation- and Nonchelation-Controlled Reductions of β-Dicarbonyl Compounds to 1,3-Diols with Three Chiral Centers
Barluenga, Jose,Resa, Julio G.,Olano, Bernardo,Fustero, Santos
, p. 1425 - 1428 (2007/10/02)
1,3-Diols 5 with three chiral centers are easily obtained, as a diastereoisomer mixture, by reduction of β-dicarbonyl compounds 4 with lithium aluminum hydrides.The diastereoisomer ratio depends largely on the solvent and the nature of the reducing agent.
