106575-53-5Relevant academic research and scientific papers
A straightforward approach to MMP-2 and MMP-9 inhibitors based on chelate claisen rearrangements
Burkhart, Jens L.,Diehl, Bjoern,Schmitt, Manfred J.,Kazmaier, Uli
experimental part, p. 567 - 575 (2012/03/10)
The chelate Claisen rearrangement is a versatile tool for the stereoselective synthesis of β-substituted γ,δ-unsaturated amino acids, which can be converted into β-substitutedaspartates by oxidative cleavage. These are ideal precursors for the synthesis o
Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines
Donkor, Isaac O.,Li, Hui,Queener, Sherry F.
, p. 605 - 611 (2007/10/03)
A series of 6-aralkyl substituted 2,4-diaminothieno[2,3-d]pyrimidines in which the 6-aryl group is separated from the thieno[2,3-d]pyrimidine ring by two to five methylene groups were synthesized and studied as inhibitors of dihydrofolate reductase from Pneumocystis carinii, Toxoplasma gondii, Mycobacterium avium, and rat liver. Compounds in which the thieno[2,3-d]pyrimidine ring is separated from the 6-aryl substituent by three methylene groups were the most potent inhibitors of the series (with IC50 values ranging from 0.24 and 11.0 μM) but those with two methylene groups between the aromatic rings were the most selective agents.
