1066-17-7 Usage
Uses
Used in Pharmaceutical Industry:
Colistin is used as an antibiotic for the treatment of severe Gram-negative bacterial infections that are resistant to other antibiotics. Its broad-spectrum activity and ability to target multidrug-resistant bacteria make it a valuable option in the fight against antibiotic-resistant infections.
Used in Hospital Settings:
In hospitals and other healthcare facilities, Colistin is used as a last-resort antibiotic for patients with life-threatening infections caused by Gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, which have developed resistance to other available treatments.
Brand Name:
Colistin is available under the brand name Coly-Mycin (Monarch).
Neurotoxicity and Nephrotoxicity
Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.
Check Digit Verification of cas no
The CAS Registry Mumber 1066-17-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,6 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1066-17:
(6*1)+(5*0)+(4*6)+(3*6)+(2*1)+(1*7)=57
57 % 10 = 7
So 1066-17-7 is a valid CAS Registry Number.
InChI:InChI=1/C53H100N16O13/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+/m1/s1
