1066-53-1

Basic information

• Product Name: METHYL METHYLPHOSPHONIC ACID
• Synonyms: METHYL METHYLPHOSPHONIC ACID
• CAS NO: 1066-53-1
• Molecular Formula: C₂H₇O₃P
• Molecular Weight: 110.05
• Mol File: 1066-53-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 159°C at 760 mmHg
• Flash Point: 50°C
• Appearance: /
• Density: 1.228g/cm³
• Vapor Pressure: 1.33mmHg at 25°C
• Refractive Index: 1.394
• CAS DataBase Reference: METHYL METHYLPHOSPHONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL METHYLPHOSPHONIC ACID(1066-53-1)
• EPA Substance Registry System: METHYL METHYLPHOSPHONIC ACID(1066-53-1)

Safety Data

• Hazardous Substances Data: 1066-53-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C2H7O3P/c1-5-6(2,3)4/h1-2H3,(H,3,4)

Upstream product

• 1066-52-0 methyl methylphosphonochloridate 
• 756-79-6 dimethyl methane phosphonate 
• 65143-05-7 O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate 
• 96203-11-1 N,N-diethyl-N-methylethanaminium methyl methylphosphonate 
• 67-56-1 methanol 
• 1284189-34-9 C₈H₁₁O₃PS 
• 151681-49-1 C₇H₉O₂PS 
• 1284189-31-6 C₇H₈FO₂PS 
• 1284189-30-5 C₇H₈ClO₂PS 
• 1236206-77-1 C₇H₇Cl₂O₂PS 
• 594-61-6 2-methyllactic acid 
• 710-09-8 methyl-phosphonic acid benzyl methyl ester 
• 7284-49-3 methyl-phosphonic acid methyl ester-(4-nitro-phenyl ester) 
• 1932-59-8 Methanphosphonsaeure-anhydrid 

Downstream Products

• 606092-24-4 6-[(methoxymethylphosphinyl)amino]-N-phenylhexaneamide 
• 606092-25-5 6-[(methoxymethylphosphinyl)oxy]-N-phenylhexaneamide 
• 756-79-6 dimethyl methane phosphonate 

Relevant articles and documents

Solid-phase synthesis of some alkyl hydrogen methylphosphonates

Eleven alkyl hydrogen methylphosphonates of structure RO(HO) P(O)Me were made by phosphoramidite chemistry on hydroxymethyl polystyrene resin; R = Me, Et, n-Pr, i-Pr, n-Bu, n-hexyl, n-octyl, cyclohexyl, cycloheptyl, cyclooctyl, and 3,3-dimethylbutan-2-yl

Synthesis of both RP and SP enantiomers of unsymmetrical methylphosphonates based on a new approach utilizing a P-ester bond with α-hydroxyacids

Condensation of methyl methylphosphonochloridate with the dilithium salt of 2-methyllactic acid gave P-racemic methylphosphonates which unexpectedly contained two units of α-hydroxyacid linked via carboxylic ester bond. The racemic mixture was chromatogra

Thermocatalytic Oxidation of Dimethyl Methylphosphonate on Supported Metal Oxides

Thermocatalytic oxidation of dimethyl methylphosphonate (DMMP) was carried out on nickel, iron, copper, and vanadium oxides supported on γ-Al2O3. The vanadium catalyst was found to exhibit exceptional catalytic activity, even better than platinum catalysts. Varying the vanadium loading from 1 to 15% by weight indicated that 10% vanadium on Al2O3 was an optimal content. In conjunction with XRD patterns, monolayer dispersion of V2O5 on Al2O3 was considered to be beneficial to the longevity of these catalysts. Different supports, including Al2O3, SiO2, and TiO2, were examined and SiO2 was the optimum support because of its large surface area and the ability to resist poisoning by P2O5. On 10% V/SiO2 catalysts, 100% (to our limit of detection of 0.1%) conversion of DMMP was reached for more than 100 h at 723 K. IR, X-ray powder diffraction, ion chromatography, and XPS results illustrated that the used catalysts contained phosphorus species. The presence of methylphosphonic acid on the catalyst surface and downstream of the packed bed reactor demonstrated the difficulty of P-CH3 cleavage. The deposition of coke in the catalyst bed and along the reactor wall resulted from the dehydration of methanol and DMMP on P2O5. Accumulation of phosphorus species and coke on catalysts gave rise to a tremendous loss of surface area. However, P2O5 itself was observed to catalyze the decomposition of DMMP. A mechanism for this reaction was proposed to explain these experimental observations.

Reaction of methyl esters of P(IV) acids with polychlorinated hydrocarbons [4]

-

Molecular mechanisms of additive fortification in model epoxy resins: A solid state NMR study

The bulk properties of polymers are often adjusted via addition of a complex blend of compounds collectively known as additives, where so-called molecular fortifiers (or antiplasticizers) may improve the mechanical properties. In the present work, insight into molecular mechanisms of additive-fortification in model epoxy resins was obtained from multinuclear solid-state NMR analysis. In particular, we have demonstrated a "free molecule"-type behavior of DMSO-d6 in DMSO-fortified resins similar to common inclusion compounds thereby revealing mere filling of free volume. In case of DMMP-fortified resins, however, chemical modification during postcure of the epoxy resin is observed yielding methyl methylphosphonate (MMP) and salt formation, where dynamic heterogeneities of MMP-d3 suggest a rather complex mechanism of fortification. The interpretation of NMR data was further supported by ab initio calculations.

VARIANTS OF PHOSPHOTRIESTERASE FOR THE HYDROLYSIS AND DETOXIFICATION OF NERVE AGENTS

Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve